MGA

Gene Information

Official Symbol: MGA
Official Name: MAX dimerization protein MGA
Aliases and Previous Symbols: N/A
Entrez ID: 23269
UniProt: Q8IWI9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	-2.82
Tubacin 1.6μM R07 exp416	-2.71
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.66
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.6
Senexin-A 25μM R07 exp400	-2.58
5-Fluorouracil 20μM R00 exp2	-2.54
Centrinone 0.5μM R07 exp343	-2.5
Tozasertib 0.1μM R07 exp414	-2.46
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.36
BML-284 0.09μM R08 exp460	-2.32
Hydroxychloroquine 30μM R08 exp490	-2.28
CoCl2 18μM R07 exp346	-2.2
Wortmannin 5μM R00 exp38	-2.2
UMK57 1μM R01 exp59	-2.17
Hydroxyurea 100μM R07 exp329	-2.13
Vinblastine 0.2μM R03 exp108	-2.04
Mitomycin-C 0.06μM R08 exp503	-1.96
FTY720 3μM R08 exp483	-1.92
LLY-283 2.6μM R06 exp290	-1.92
Rotenone 20μM R00 exp34	-1.92
CI-1040 9.5μM R08 exp472	-1.89
Cryptotanshinone 12μM R05 exp227	-1.89
HMS-I1 1μM R01 exp46	-1.87
GSK626616 14μM R08 exp485	-1.84
NFN1 0.4μM R03 exp99	-1.84
CB-5083 0.4μM R08 exp468	-1.81
CCT251545 0.2μM R06 exp271	-1.81
Nutlin-3A 1.6μM R06 exp294	-1.8
Diepoxybutane 3μM R07 exp354	-1.79
Thimerosal 0.85μM R08 exp529	-1.79
TRAIL 50ng/ml R00 exp36	-1.74
Lead acetate 2000μM R08 exp497	-1.73
Thapsigargin 0.005μM R07 exp407	-1.7
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.5
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.57
MLN-4924 0.2μM R00 exp21	2.63
THZ531 0.11μM R07 exp409	2.72
THZ531 0.225μM R08 exp444	3.31
THZ531 0.11 to 0.175μM on day4 R07 exp413	3.44

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6021
Expression level (log2 read counts): 7.52

Expression Distribution

Gene	Correlation
RRM1	0.483
C19orf53	0.467
MRTO4	0.412

T-box
HLH

MLL1 complex
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
RNA polymerase II activating transcription factor binding
cell fate specification
protein dimerization activity
cell fate commitment
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell cycle process
DNA-binding transcription activator activity, RNA polymerase II-specific
negative regulation of cell cycle
regulation of cell cycle process
negative regulation of transcription by RNA polymerase II
regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process