SYNGR3

Entrez Summary: N/A
UniProt Summary: May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. {ECO:0000250|UniProtKB:Q8R191}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neurotransmitter uptake
SH2 domain binding
substantia nigra development
neural nucleus development
synaptic vesicle membrane
neuromuscular junction
midbrain development
protein N-terminus binding
positive regulation of transporter activity
synaptic vesicle
neurotransmitter transport
regulation of transporter activity
regulation of neurotransmitter levels
cell junction
import into cell
regulated exocytosis
brain development
head development
exocytosis
central nervous system development
positive regulation of transport
secretion by cell
export from cell
secretion
positive regulation of molecular function
regulation of transport
vesicle-mediated transport