IDS

• Official Symbol: IDS
• Official Name: iduronate 2-sulfatase
• Aliases and Previous Symbols: N/A
• Entrez ID: 3423
• UniProt: P22304
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. COMPLETENESS: complete on the 3' end.
• UniProt Summary: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 17682
• Expression level (log2 read counts): 4.86

Expression Distribution

×

IDS Expression in NALM6 Cells: 4.86