IDS [The Human Chemical-Genetic Interaction Map Project]

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======= IDS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDS
  * **<color #00a2e8>Official Name</color>**: iduronate 2-sulfatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3423|3423]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22304|P22304]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300823|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iduronate-2-sulfatase activity|
|sulfuric ester hydrolase activity|
|chondroitin sulfate catabolic process|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan metabolic process|
|lysosomal lumen|
|mucopolysaccharide metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|carbohydrate derivative catabolic process|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17682
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDS Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>