TMEM14A

Entrez Summary: N/A
UniProt Summary: Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. {ECO:0000269|PubMed:21723035}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of mitochondrion organization
regulation of mitochondrial membrane permeability
regulation of membrane permeability
mitochondrial membrane
mitochondrial membrane organization
regulation of mitochondrion organization
mitochondrial transport
negative regulation of apoptotic signaling pathway
negative regulation of organelle organization
regulation of apoptotic signaling pathway
mitochondrion organization
negative regulation of transport
negative regulation of cellular component organization
membrane organization
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
endoplasmic reticulum membrane
negative regulation of cell death
programmed cell death
cell death
negative regulation of signal transduction
regulation of organelle organization
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
regulation of cell death
regulation of transport