HOMER1

Entrez Summary: N/A
UniProt Summary: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
G protein-coupled glutamate receptor binding
neuron spine
regulation of dendritic spine maintenance
signaling adaptor activity
regulation of postsynaptic neurotransmitter receptor activity
chemical homeostasis within a tissue
regulation of store-operated calcium entry
G protein-coupled glutamate receptor signaling pathway
postsynaptic cytosol
costamere
behavioral response to cocaine
skeletal muscle fiber development
myotube cell development
skeletal muscle contraction
regulation of calcium ion import
multicellular organismal movement
musculoskeletal movement
glutamate receptor signaling pathway
response to cocaine
myotube differentiation
muscle fiber development
regulation of synaptic transmission, glutamatergic
apical part of cell
regulation of neurotransmitter receptor activity
response to anesthetic
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of postsynapse organization
striated muscle contraction
response to alkaloid
positive regulation of calcium ion transport
skeletal muscle tissue development
ion channel binding
Z disc
skeletal muscle organ development
striated muscle cell development
regulation of nervous system process
adult behavior
muscle cell development
dendritic spine