HOMER1 [The Human Chemical-Genetic Interaction Map Project]

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======= HOMER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOMER1
  * **<color #00a2e8>Official Name</color>**: homer scaffold protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9456|9456]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YM7|Q86YM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOMER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOMER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase C-activating G protein-coupled glutamate receptor signaling pathway|
|G protein-coupled glutamate receptor binding|
|neuron spine|
|regulation of dendritic spine maintenance|
|signaling adaptor activity|
|regulation of postsynaptic neurotransmitter receptor activity|
|chemical homeostasis within a tissue|
|regulation of store-operated calcium entry|
|G protein-coupled glutamate receptor signaling pathway|
|postsynaptic cytosol|
|costamere|
|behavioral response to cocaine|
|skeletal muscle fiber development|
|myotube cell development|
|skeletal muscle contraction|
|regulation of calcium ion import|
|multicellular organismal movement|
|musculoskeletal movement|
|glutamate receptor signaling pathway|
|response to cocaine|
|myotube differentiation|
|muscle fiber development|
|regulation of synaptic transmission, glutamatergic|
|apical part of cell|
|regulation of neurotransmitter receptor activity|
|response to anesthetic|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of postsynapse organization|
|striated muscle contraction|
|response to alkaloid|
|positive regulation of calcium ion transport|
|skeletal muscle tissue development|
|ion channel binding|
|Z disc|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of nervous system process|
|adult behavior|
|muscle cell development|
|dendritic spine|
|protein tetramerization|
|response to calcium ion|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|response to ammonium ion|
|tissue homeostasis|
|postsynaptic membrane|
|striated muscle cell differentiation|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|muscle cell differentiation|
|regulation of calcium ion transport|
|muscle contraction|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|striated muscle tissue development|
|muscle organ development|
|axon|
|muscle tissue development|
|muscle system process|
|response to xenobiotic stimulus|
|neuron projection|
|multicellular organismal homeostasis|
|regulation of cation transmembrane transport|
|anatomical structure homeostasis|
|glutamatergic synapse|
|response to metal ion|
|regulation of metal ion transport|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|muscle structure development|
|regulation of ion transmembrane transport|
|protein complex oligomerization|
|response to inorganic substance|
|cell junction|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|response to organic cyclic compound|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|G protein-coupled receptor signaling pathway|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOMER1 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>