TRA2A

Entrez Summary: N/A
UniProt Summary: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.08
Etoposide 1μM R00 exp19	-1.84
Dynasore 10μM R04 exp180	1.7
Dimethyloxaloylglycine 11μM R07 exp314	1.72
All-trans-Retinoic-Acid 40μM R07 exp334	1.75
DABN racemic mixture R03 exp93	1.75
NMS-873 0.07μM R07 exp380	1.78
BI-D1870 2μM R04 exp162	1.88
Menadione 5μM R06 exp292	1.96
Oligomycin-A 2μM R00 exp25	2.07
CB-5083 0.4μM R08 exp468	2.2
SB743921 0.001μM R05 exp244	2.22
Rotenone 2μM R00 exp33	2.4
HMS-I1 10μM R06 exp256	2.54
Nocodazole 0.1μM R03 exp94	2.88

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mRNA splicing, via spliceosome
positive regulation of mRNA processing
positive regulation of RNA splicing
positive regulation of mRNA metabolic process
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
ribonucleoprotein complex
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
mRNA processing
intracellular membrane-bounded organelle
mRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of gene expression
gene expression