RAB11FIP2

Entrez Summary: N/A
UniProt Summary: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2
RBD-FIP

TRAM-dependent toll-like receptor 4 signaling pathway
TRAM-dependent toll-like receptor signaling pathway
insulin secretion involved in cellular response to glucose stimulus
toll-like receptor 4 signaling pathway
phagocytic cup
MyD88-independent toll-like receptor signaling pathway
renal water homeostasis
insulin secretion
positive regulation of protein localization to plasma membrane
peptide hormone secretion
positive regulation of protein localization to cell periphery
multicellular organismal water homeostasis
cellular response to glucose stimulus
cellular response to hexose stimulus
hormone secretion
cellular response to monosaccharide stimulus
water homeostasis
cellular response to carbohydrate stimulus
hormone transport
recycling endosome membrane
cellular glucose homeostasis
regulation of protein localization to plasma membrane
cell projection
toll-like receptor signaling pathway
renal system process
regulation of protein localization to cell periphery
establishment of cell polarity
positive regulation of protein localization to membrane
pattern recognition receptor signaling pathway
response to glucose
cytoplasmic vesicle membrane
response to hexose
response to monosaccharide
Rab GTPase binding
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
response to carbohydrate
peptide secretion