ZFP57
Gene Information
- Official Symbol: ZFP57
- Official Name: ZFP57 zinc finger protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 346171
- UniProt: Q9NU63
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009].
- UniProt Summary: Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. {ECO:0000250, ECO:0000269|PubMed:18622393}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10391
- Expression level (log2 read counts): -7.68
ZFP57 Expression in NALM6 Cells: -7.68
