HMGN1

Entrez Summary: N/A
UniProt Summary: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of NAD+ ADP-ribosyltransferase activity
post-embryonic camera-type eye morphogenesis
positive regulation of NAD+ ADP-ribosyltransferase activity
pyrimidine dimer repair by nucleotide-excision repair
post-embryonic eye morphogenesis
post-embryonic camera-type eye development
post-embryonic animal organ morphogenesis
pyrimidine dimer repair
post-embryonic animal morphogenesis
regulation of development, heterochronic
post-embryonic animal organ development
response to UV-C
response to UV-B
positive regulation of DNA-templated transcription, elongation
nucleosomal DNA binding
regulation of DNA-templated transcription, elongation
transcription-coupled nucleotide-excision repair
post-embryonic development
nucleotide-excision repair
camera-type eye morphogenesis
chromatin
response to UV
eye morphogenesis
sensory organ morphogenesis
response to light stimulus
camera-type eye development
regulation of epithelial cell proliferation
eye development
visual system development
sensory system development
response to radiation
DNA repair
sensory organ development
positive regulation of transferase activity
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
animal organ morphogenesis
regulation of transferase activity
chromosome organization