FAM175A

Entrez Summary: This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
UniProt Summary: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Etoposide 0.1μM R05 exp198	-2.37
Dorsomorphin 5μM R07 exp357	-1.77

Gene	Correlation
RRM1	0.46
BRE	0.413

BRCA1-A complex
signal transduction involved in G2 DNA damage checkpoint
G2 DNA damage checkpoint
polyubiquitin modification-dependent protein binding
double-strand break repair via nonhomologous end joining
non-recombinational repair
positive regulation of DNA repair
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
positive regulation of response to DNA damage stimulus
negative regulation of cell cycle G2/M phase transition
signal transduction in response to DNA damage
regulation of DNA repair
DNA damage checkpoint
DNA integrity checkpoint
response to ionizing radiation
double-strand break repair
cell cycle checkpoint
positive regulation of DNA metabolic process
regulation of cell cycle G2/M phase transition
regulation of response to DNA damage stimulus
negative regulation of cell cycle phase transition
protein deubiquitination
nuclear body
protein modification by small protein removal
negative regulation of cell cycle process
regulation of DNA metabolic process
response to radiation
regulation of cell cycle phase transition
DNA repair
negative regulation of cell cycle
chromatin organization
regulation of cellular response to stress
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
chromosome organization
response to abiotic stimulus