ZIC3

Entrez Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:17764085}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

determination of left/right asymmetry in nervous system
determination of pancreatic left/right asymmetry
determination of liver left/right asymmetry
determination of digestive tract left/right asymmetry
heart looping
somatic stem cell population maintenance
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
pancreas development
embryonic heart tube development
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
liver development
hepaticobiliary system development
digestive tract development
stem cell population maintenance
maintenance of cell number
digestive system development
lung development
respiratory tube development
respiratory system development
anterior/posterior pattern specification
heart morphogenesis
embryonic organ morphogenesis
epithelial tube morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
gland development
sequence-specific DNA binding
morphogenesis of an epithelium
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
heart development
tissue morphogenesis
embryonic morphogenesis
tube morphogenesis
DNA-binding transcription factor activity