NT5C3B

Gene Information
  • Official Symbol: NT5C3B
  • Official Name: 5'-nucleotidase, cytosolic IIIB
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 115024
  • UniProt: Q969T7
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233). {ECO:0000269|PubMed:23223233, ECO:0000269|PubMed:24603684}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 14540
  • Expression level (log2 read counts): 4.95

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1