CNOT8
Gene Information
- Official Symbol: CNOT8
- Official Name: CCR4-NOT transcription complex subunit 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 9337
- UniProt: Q9UFF9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.
Pfam Domains GO Terms
Pfam Domains
| CAF1 |
GO Terms
| CCR4-NOT core complex |
| poly(A)-specific ribonuclease activity |
| CCR4-NOT complex |
| nuclear-transcribed mRNA poly(A) tail shortening |
| 3-5-exoribonuclease activity |
| exonucleolytic catabolism of deadenylated mRNA |
| nuclear-transcribed mRNA catabolic process, exonucleolytic |
| RNA phosphodiester bond hydrolysis, exonucleolytic |
| gene silencing by miRNA |
| positive regulation of mRNA catabolic process |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| posttranscriptional gene silencing by RNA |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| posttranscriptional gene silencing |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| G1 DNA damage checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of mRNA metabolic process |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| P-body |
| gene silencing by RNA |
| intracellular |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| negative regulation of translation |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| negative regulation of cellular amide metabolic process |
| regulation of G1/S transition of mitotic cell cycle |
| gene silencing |
| mitotic cell cycle checkpoint |
| RNA phosphodiester bond hydrolysis |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| regulation of mRNA catabolic process |
| negative regulation of mitotic cell cycle phase transition |
| mRNA catabolic process |
| negative regulation of cell cycle phase transition |
| regulation of gene expression, epigenetic |
| RNA catabolic process |
| positive regulation of cell cycle process |
| nucleic acid phosphodiester bond hydrolysis |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| regulation of translation |
| positive regulation of cellular catabolic process |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| regulation of cellular amide metabolic process |
| regulation of mitotic cell cycle phase transition |
| positive regulation of catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| organic cyclic compound catabolic process |
| posttranscriptional regulation of gene expression |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| mitotic cell cycle |
| mRNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| regulation of cellular catabolic process |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| regulation of catabolic process |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| organic cyclic compound biosynthetic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14226
- Expression level (log2 read counts): 6.24
Expression Distribution
CNOT8 Expression in NALM6 Cells: 6.24
