BTG2

Gene Information

Official Symbol: BTG2
Official Name: BTG anti-proliferation factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 7832
UniProt: P78543
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008].
UniProt Summary: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10337
Expression level (log2 read counts): 5.46

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.1
Mdivi-1 15μM R05 exp217	-1.86
I-BRD9 4μM R07 exp365	3.85

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of nuclear-transcribed mRNA poly(A) tail shortening
dentate gyrus development
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of neural precursor cell proliferation
response to electrical stimulus
positive regulation of mRNA catabolic process
skeletal muscle cell differentiation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic DNA integrity checkpoint
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA damage checkpoint
mitotic G1/S transition checkpoint
mitotic G1 DNA damage checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
associative learning
positive regulation of mRNA metabolic process
DNA damage response, signal transduction by p53 class mediator
central nervous system neuron development
positive regulation of cell cycle arrest
hippocampus development
regulation of neural precursor cell proliferation
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
signal transduction in response to DNA damage
mitotic DNA integrity checkpoint
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
limbic system development
signal transduction by p53 class mediator
skeletal muscle tissue development
negative regulation of translation
DNA damage checkpoint
skeletal muscle organ development