ZNF737

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
YM155 0.0002μM R01 exp61	-2.89
SNS-032 15μM R08 exp443	-2.39
AICAR 240μM R03 exp116	-2.07
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.96
Lapatinib 5μM R01 exp47	-1.86
Dimethyloxaloylglycine 100μM R05 exp229	-1.73
Disulfiram 4.3μM R06 exp281	-1.7
Nicotinate 1000μM R03 exp140	1.72
Myriocin 25μM R06 exp293	1.75
Arsenic trioxide 60μM R08 exp449	1.76
Nocodazole 0.1μM R03 exp94	1.78
GSK-J5 1.5μM R08 exp484	1.84
QNZ 0.01μM R05 exp241	1.85
Cycloheximide 0.2μM R00 exp15	1.87
Thimerosal 0.85μM R08 exp529	1.93
Lead acetate 990μM R08 exp496	2.03
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.1
CI-1040 9.5μM R08 exp472	2.2
Quercetin 20μM R08 exp517	2.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C2H2
KRAB

nucleic acid binding
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific