ZBTB8OS

Entrez Summary: N/A
UniProt Summary: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. {ECO:0000269|PubMed:24870230}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
VE-822 0.04μM R06 exp300	-1.92
Thioridazine 5μM R08 exp530	1.7
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.72
A-366 10μM R03 exp115	1.81
Pimelic-diphenylamide-106 5μM R00 exp28	1.88
Etoposide 1μM R00 exp19	1.97
Nifuroxazide 5μM R03 exp102	2.27
MLN-4924 2μM R00 exp22	2.28

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA-splicing ligase complex
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
tRNA processing
tRNA metabolic process
ncRNA processing
RNA splicing
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression