USP51

Entrez Summary: N/A
UniProt Summary: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998). {ECO:0000269|PubMed:27083998}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-1.78
BI-2536 0.0042μM R03 exp95	-1.73
UM0011500 10μM R05 exp246	-1.71
WNT3A 44ng/ml R08 exp537	1.75
HMS-I2 5μM R06 exp287	1.87
Hippuristanol 0.12μM R08 exp488	1.9
All-trans-Retinoic-Acid 40μM R07 exp334	2
39°C R06 exp303	2.25
VE-822 0.04μM R06 exp300	2.51

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

zf-UBP
UCH

histone deubiquitination
regulation of double-strand break repair via nonhomologous end joining
regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
regulation of DNA recombination
thiol-dependent ubiquitin-specific protease activity
chromosome
regulation of DNA repair
histone binding
regulation of response to DNA damage stimulus
protein deubiquitination
protein modification by small protein removal
regulation of DNA metabolic process
histone modification
covalent chromatin modification
chromatin binding
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
chromatin organization
regulation of cellular response to stress
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
zinc ion binding
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
chromosome organization
regulation of cell cycle
proteolysis
regulation of response to stress
cellular response to stress
organic substance catabolic process
cellular catabolic process