CENPA

Gene Information

Official Symbol: CENPA
Official Name: centromere protein A
Aliases and Previous Symbols: N/A
Entrez ID: 1058
UniProt: P49450
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-2.46
L-74142 5μM R03 exp131	-2.41
GSK-J4 1μM R07 exp362	-2.29
35°C R06 exp302	-1.87
Quercetin 20μM R08 exp517	-1.85
BI-6727 0.0125μM R03 exp97	-1.82
Arsenic trioxide 60μM R08 exp449	-1.81

Global Fraction of Cell Lines Where Essential: 368/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	15/28
blood	10/28
bone	8/25
breast	13/33
central nervous system	28/56
cervix	4/4
colorectal	11/17
esophagus	11/13
fibroblast	1/1
gastric	6/15
kidney	8/21
liver	7/20
lung	43/75
lymphocyte	8/14
ovary	9/26
pancreas	17/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	0/1
skin	9/24
soft tissue	2/7
thyroid	2/2
upper aerodigestive	18/22
urinary tract	21/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 197
Expression level (log2 read counts): 4.84

Expression Distribution

Gene	Correlation
C14orf80	0.464
GEMIN8	0.458
TUBD1	0.434

condensed chromosome inner kinetochore
nuclear pericentric heterochromatin
condensed nuclear chromosome kinetochore
kinetochore assembly
condensed nuclear chromosome, centromeric region
nuclear nucleosome
protein localization to chromosome, centromeric region
kinetochore organization
establishment of mitotic spindle orientation
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
establishment of mitotic spindle localization
chromatin remodeling at centromere
establishment of spindle orientation
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
establishment of spindle localization
nucleosomal DNA binding
histone exchange
spindle localization
chromosome, centromeric region
protein localization to chromosome
mitotic cytokinesis
nucleosome
ATP-dependent chromatin remodeling
cytoskeleton-dependent cytokinesis
cytokinesis
microtubule cytoskeleton organization involved in mitosis
nucleosome assembly
establishment of cell polarity
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
establishment or maintenance of cell polarity
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change