CXCL12

Gene Information

Official Symbol: CXCL12
Official Name: C-X-C motif chemokine ligand 12
Aliases and Previous Symbols: N/A
Entrez ID: 6387
UniProt: P48061
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14313
Expression level (log2 read counts): -5.01

Expression Distribution

Screen	Score
Thioridazine 5μM R08 exp530	1.7
L-74142 5μM R03 exp131	1.97

response to ultrasound
CXCR chemokine receptor binding
chemokine (C-X-C motif) ligand 12 signaling pathway
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte adhesion to vascular endothelial cell
positive regulation of dopamine secretion
positive regulation of axon extension involved in axon guidance
negative regulation of dendritic cell apoptotic process
chemokine receptor binding
positive regulation of axon guidance
regulation of leukocyte tethering or rolling
negative regulation of cellular extravasation
integrin activation
regulation of dendritic cell apoptotic process
positive regulation of catecholamine secretion
detection of mechanical stimulus involved in sensory perception of pain
induction of positive chemotaxis
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
positive regulation of monocyte chemotaxis
regulation of leukocyte adhesion to vascular endothelial cell
detection of temperature stimulus
positive regulation of calcium ion import
sensory perception of temperature stimulus
positive regulation of mononuclear cell migration
regulation of monocyte chemotaxis
positive regulation of positive chemotaxis
regulation of positive chemotaxis
detection of mechanical stimulus involved in sensory perception
regulation of cellular extravasation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of response to drug
positive regulation of T cell migration
regulation of axon extension involved in axon guidance
positive regulation of amine transport
positive regulation of lymphocyte migration
regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of calcium ion import
regulation of dopamine secretion
positive regulation of axon extension