Thioridazine 5μM R08 exp530 [The Human Chemical-Genetic Interaction Map Project]

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====== Thioridazine 5μM R08 exp530 ======
==== Mechanism of Action ====
DRD2/4 selectivity, causes cardiac arrhythmia, also has antibiotic activity against M. tuberculosis
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Antagonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Thioridazine hydrochloride%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 130-61-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/66062|66062]]
    * **<color #00a2e8>IUPAC:</color>** %%10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
    * **<color #00a2e8>INCHI Key:</color>** NZFNXWQNBYZDAQ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 407
    * **<color #00a2e8>Canonical SMILES:</color>** CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C21H27ClN2S2
{{:chemogenomics:structures:chem-0334.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** T9025
    * **<color #00a2e8>Lot #:</color>** BCBV1701
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C21H26N2S2 371.16102; found 371.16222
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Thioridazine
    * **<color #00a2e8>Min:</color>** -11.3787; **<color #00a2e8>Max:</color>** 99.9166
{{:chemogenomics:dose_response:dr_629.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |4.4700    |
| IC20  |5.0190    |
| IC30  |5.4210    |
| IC40  |5.7740    |
| IC50  |6.1180    |
| IC60  |6.4830    |
| IC70  |6.9050    |
| IC80  |7.4580    |
| IC90  |8.3730    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.2
    * **<color #00a2e8>Numbers of reads</color>**: 15363012


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|16/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Thioridazine_5uM_Round-8_exp530.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Thioridazine 5μM R08 exp530'>
{{:chemogenomics:cranks_plots:exp530.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC5A3|SLC5A3]]|-5.08|<0.01|
|[[:human_genes:D:DAGLB|DAGLB]]|-3.63|<0.01|
|[[:human_genes:R:RGP1|RGP1]]|-3.47|<0.01|
|[[:human_genes:A:ARL1|ARL1]]|-3.31|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.30|<0.01|
|[[:human_genes:G:GPR107|GPR107]]|-3.15|<0.01|
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-3.13|<0.01|
|[[:human_genes:V:VAC14|VAC14]]|-3.11|<0.01|
|[[:human_genes:S:SCYL1|SCYL1]]|-3.09|<0.01|
|[[:human_genes:M:MME|MME]]|-2.83|<0.01|
|[[:human_genes:N:NPC2|NPC2]]|-2.60|0.02|
|[[:human_genes:C:CHKA|CHKA]]|-2.60|0.02|
|[[:human_genes:F:FDPS|FDPS]]|-2.58|0.04|
|[[:human_genes:A:ARPC4|ARPC4]]|-2.53|0.02|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.48|0.03|
|[[:human_genes:J:JTB|JTB]]|-2.46|0.03|
|[[:human_genes:F:FAF2|FAF2]]|-2.44|0.13|
|[[:human_genes:E:EHBP1L1|EHBP1L1]]|-2.43|0.07|
|[[:human_genes:R:RALGAPB|RALGAPB]]|-2.36|0.05|
|[[:human_genes:C:CNOT4|CNOT4]]|-2.26|0.08|
|[[:human_genes:M:MTMR6|MTMR6]]|-2.25|0.24|
|[[:human_genes:K:KHDRBS1|KHDRBS1]]|-2.24|0.09|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.19|0.11|
|[[:human_genes:S:SKA1|SKA1]]|-2.16|0.12|
|[[:human_genes:H:HIST1H3B|HIST1H3B]]|-2.15|0.21|
|[[:human_genes:A:AGPAT1|AGPAT1]]|-2.14|0.33|
|[[:human_genes:V:VN1R4|VN1R4]]|-2.10|0.16|
|[[:human_genes:Z:ZSWIM8|ZSWIM8]]|-2.09|0.24|
|[[:human_genes:S:SMAD7|SMAD7]]|-2.08|0.17|
|[[:human_genes:T:TCF4|TCF4]]|-2.07|0.18|
|[[:human_genes:P:PLA2G4D|PLA2G4D]]|1.93|0.54|
|[[:human_genes:H:HSPB3|HSPB3]]|1.94|0.53|
|[[:human_genes:E:EPPIN|EPPIN]]|1.94|0.53|
|[[:human_genes:I:IKZF1|IKZF1]]|1.95|0.53|
|[[:human_genes:A:ANKRD11|ANKRD11]]|1.95|0.53|
|[[:human_genes:C:CDKN1A|CDKN1A]]|1.95|0.53|
|[[:human_genes:C:CSTF2T|CSTF2T]]|1.96|0.53|
|[[:human_genes:N:NPRL2|NPRL2]]|1.99|0.54|
|[[:human_genes:N:NDUFA2|NDUFA2]]|2.01|0.54|
|[[:human_genes:C:CACNA1S|CACNA1S]]|2.01|0.54|
|[[:human_genes:N:NYAP2|NYAP2]]|2.01|0.53|
|[[:human_genes:L:LYRM7|LYRM7]]|2.02|0.53|
|[[:human_genes:K:KRT4|KRT4]]|2.02|0.53|
|[[:human_genes:C:COBLL1|COBLL1]]|2.04|0.53|
|[[:human_genes:E:ELL|ELL]]|2.04|0.53|
|[[:human_genes:N:NPRL3|NPRL3]]|2.04|0.54|
|[[:human_genes:C:C19orf53|C19orf53]]|2.04|0.54|
|[[:human_genes:K:KPNB1|KPNB1]]|2.09|0.63|
|[[:human_genes:T:TYMS|TYMS]]|2.10|0.54|
|[[:human_genes:E:ENPP4|ENPP4]]|2.17|0.53|
|[[:human_genes:S:SLC8B1|SLC8B1]]|2.20|0.46|
|[[:human_genes:P:PRPF19|PRPF19]]|2.23|0.54|
|[[:human_genes:S:SHMT2|SHMT2]]|2.24|0.53|
|[[:human_genes:S:SUB1|SUB1]]|2.24|0.53|
|[[:human_genes:P:PSMD8|PSMD8]]|2.27|0.47|
|[[:human_genes:K:KIAA1671|KIAA1671]]|2.29|0.34|
|[[:human_genes:K:KCNJ4|KCNJ4]]|2.29|0.47|
|[[:human_genes:Z:ZNF521|ZNF521]]|2.32|0.34|
|[[:human_genes:I:IK|IK]]|2.32|0.34|
|[[:human_genes:Z:ZNF91|ZNF91]]|2.85|0.05|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.096|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.06|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|0.059|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.056|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.12|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.104|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.098|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.096|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.091|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.086|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.085|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.079|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.076|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.076|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.07|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.068|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.066|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.065|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.065|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.062|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp124|GSK343 3μM R03 exp124]]|0.06|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.059|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.059|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp433|LJH685 50μM R08 exp433]]|0.058|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|0.057|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.056|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.056|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.054|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.052|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp358|FK-506 5μM R07 exp358]]|0.052|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.051|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|0.051|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.051|<button type="primary" size="small" modal="33">View</button>|
</modal>


<modal id="1" size="lg" title="Thioridazine 5μM R08 exp530  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp530.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Thioridazine 5μM R08 exp530  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp530_vs_exp90.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Thioridazine 5μM R08 exp530  vs  UNC1999 2μM R03 exp155">
{{:chemogenomics:comparison_plots:exp155_vs_exp530.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Thioridazine 5μM R08 exp530  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp530.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp344_vs_exp530.png?nolink |}}
</modal>

<modal id="6" size="lg" title="NN-Dimethylsphingosine 2.5μM R08 exp508  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp508_vs_exp530.png?nolink |}}
</modal>

<modal id="7" size="lg" title="FTY720 3μM R08 exp483  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp483_vs_exp530.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Hydroxychloroquine 30μM R08 exp490  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp490_vs_exp530.png?nolink |}}
</modal>

<modal id="9" size="lg" title="BS-181 20μM R08 exp461  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp461_vs_exp530.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Ibrutinib 10μM R08 exp442  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp442_vs_exp530.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CCT251545 20μM R07 exp326  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp326_vs_exp530.png?nolink |}}
</modal>

<modal id="12" size="lg" title="IU1-47 25μM R04 exp182  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp182_vs_exp530.png?nolink |}}
</modal>

<modal id="13" size="lg" title="EPZ-5676 30μM R05 exp233  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp233_vs_exp530.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp454_vs_exp530.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp465_vs_exp530.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp457_vs_exp530.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp269_vs_exp530.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Chloroquine 32μM R08 exp470  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp470_vs_exp530.png?nolink |}}
</modal>

<modal id="19" size="lg" title="BH1 1μM R04 exp169  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp169_vs_exp530.png?nolink |}}
</modal>

<modal id="20" size="lg" title="B02 10μM R08 exp453  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp453_vs_exp530.png?nolink |}}
</modal>

<modal id="21" size="lg" title="GSK343 3μM R03 exp124  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp124_vs_exp530.png?nolink |}}
</modal>

<modal id="22" size="lg" title="FK-506 30μM R07 exp359  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp359_vs_exp530.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp164_vs_exp530.png?nolink |}}
</modal>

<modal id="24" size="lg" title="LJH685 50μM R08 exp433  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp433_vs_exp530.png?nolink |}}
</modal>

<modal id="25" size="lg" title="SGC0946 7μM R03 exp151  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp151_vs_exp530.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp530_vs_exp68.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp530_vs_exp77.png?nolink |}}
</modal>

<modal id="28" size="lg" title="CB-839 10μM R05 exp224  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp224_vs_exp530.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Azithromycin 100μM R08 exp452  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp452_vs_exp530.png?nolink |}}
</modal>

<modal id="30" size="lg" title="FK-506 5μM R07 exp358  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp358_vs_exp530.png?nolink |}}
</modal>

<modal id="31" size="lg" title="CFI-400945 25μM R08 exp469  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp469_vs_exp530.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Nicotine 3000μM R08 exp510  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp510_vs_exp530.png?nolink |}}
</modal>

<modal id="33" size="lg" title="SB203580 25μM R03 exp149  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp149_vs_exp530.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|phospholipid biosynthetic process|15.80|VAC14,CHKA,FDPS,PCYT1A,MTMR6,AGPAT1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>