B02 10μM R08 exp453 [The Human Chemical-Genetic Interaction Map Project]

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====== B02 10μM R08 exp453 ======
==== Mechanism of Action ====
Inhibits RAD51 recombinase, blocks homologous recombination
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Repair Protein Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%RAD51 inhibitor B02%%
    * **<color #00a2e8>Synonyms:</color>** B02
    * **<color #00a2e8>CAS #:</color>** 1290541-46-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5738263|5738263]]
    * **<color #00a2e8>IUPAC:</color>** %%3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
    * **<color #00a2e8>INCHI Key:</color>** GEKDQXSPTHHANP-OUKQBFOZSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 339.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C(C=C1)CN2C(=NC3=CC=CC=C3C2=O)C=CC4=CN=CC=C4
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC=C(C=C1)CN2C(=NC3=CC=CC=C3C2=O)/C=C/C4=CN=CC=C4
    * **<color #00a2e8>Molecular Formula:</color>** C22H17N3O
{{:chemogenomics:structures:chem-0264.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Cayman Chemical
    * **<color #00a2e8>Catalog #:</color>** 22133
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C22 H17 N3 O 340.14444; found 340.14521
</panel>


<panel title='Dose Response Curve'>
Dose response curve not available.
</panel>


</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.0
    * **<color #00a2e8>Numbers of reads</color>**: 15314133


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|11/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/B02_10uM_Round-8_exp453.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='B02 10μM R08 exp453'>
{{:chemogenomics:cranks_plots:exp453.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:K:KDSR|KDSR]]|-4.32|<0.01|
|[[:human_genes:T:TTC37|TTC37]]|-4.26|<0.01|
|[[:human_genes:U:UXS1|UXS1]]|-4.07|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.78|<0.01|
|[[:human_genes:A:ALG9|ALG9]]|-3.37|<0.01|
|[[:human_genes:K:KIF18A|KIF18A]]|-3.32|<0.01|
|[[:human_genes:F:FDPS|FDPS]]|-2.74|0.03|
|[[:human_genes:S:SKIV2L|SKIV2L]]|-2.70|0.06|
|[[:human_genes:R:RABGEF1|RABGEF1]]|-2.60|0.05|
|[[:human_genes:D:DNAJC3|DNAJC3]]|-2.59|0.03|
|[[:human_genes:A:ARL2|ARL2]]|-2.52|0.13|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.49|0.04|
|[[:human_genes:F:FBXO7|FBXO7]]|-2.46|0.04|
|[[:human_genes:S:SEC16A|SEC16A]]|-2.37|0.20|
|[[:human_genes:I:ILF3|ILF3]]|-2.31|0.29|
|[[:human_genes:N:NCDN|NCDN]]|-2.29|0.10|
|[[:human_genes:T:TBCD|TBCD]]|-2.26|0.20|
|[[:human_genes:C:CSK|CSK]]|-2.23|0.13|
|[[:human_genes:R:RCE1|RCE1]]|-2.21|0.13|
|[[:human_genes:T:TUT1|TUT1]]|-2.20|0.20|
|[[:human_genes:L:LCMT1|LCMT1]]|-2.19|0.14|
|[[:human_genes:A:ARL1|ARL1]]|-2.17|0.14|
|[[:human_genes:N:NAPG|NAPG]]|-2.14|0.15|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.14|0.15|
|[[:human_genes:A:ADAR|ADAR]]|-2.14|0.19|
|[[:human_genes:A:ALG6|ALG6]]|-2.12|0.16|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.12|0.20|
|[[:human_genes:H:HIST1H1B|HIST1H1B]]|-2.10|0.17|
|[[:human_genes:L:LAMTOR4|LAMTOR4]]|-2.09|0.17|
|[[:human_genes:T:TNFAIP2|TNFAIP2]]|-2.09|0.26|
|[[:human_genes:H:HEXIM1|HEXIM1]]|2.00|0.30|
|[[:human_genes:T:TFIP11|TFIP11]]|2.00|0.30|
|[[:human_genes:R:RPS19BP1|RPS19BP1]]|2.01|0.30|
|[[:human_genes:M:MYH7B|MYH7B]]|2.01|0.48|
|[[:human_genes:A:AKT1|AKT1]]|2.02|0.30|
|[[:human_genes:D:DNAJC17|DNAJC17]]|2.03|0.51|
|[[:human_genes:C:CORT|CORT]]|2.07|0.24|
|[[:human_genes:P:PCCB|PCCB]]|2.09|0.24|
|[[:human_genes:S:SMC1B|SMC1B]]|2.12|0.21|
|[[:human_genes:X:XRN2|XRN2]]|2.14|0.49|
|[[:human_genes:H:HLA-C|HLA-C]]|2.16|0.18|
|[[:human_genes:A:ARID4A|ARID4A]]|2.16|0.18|
|[[:human_genes:G:GTPBP4|GTPBP4]]|2.19|0.46|
|[[:human_genes:A:ALDH1A3|ALDH1A3]]|2.22|0.16|
|[[:human_genes:R:RICTOR|RICTOR]]|2.24|0.15|
|[[:human_genes:P:PML|PML]]|2.24|0.15|
|[[:human_genes:U:UBE4B|UBE4B]]|2.26|0.15|
|[[:human_genes:E:ENO2|ENO2]]|2.30|0.18|
|[[:human_genes:R:RPS15A|RPS15A]]|2.30|0.64|
|[[:human_genes:R:RMI2|RMI2]]|2.33|0.15|
|[[:human_genes:R:RBM38|RBM38]]|2.36|0.15|
|[[:human_genes:P:PAQR6|PAQR6]]|2.38|0.15|
|[[:human_genes:P:POLR2J2|POLR2J2]]|2.39|0.62|
|[[:human_genes:H:HTRA2|HTRA2]]|2.53|0.13|
|[[:human_genes:N:NCBP1|NCBP1]]|2.53|0.24|
|[[:human_genes:C:CD19|CD19]]|2.56|0.15|
|[[:human_genes:N:NPRL2|NPRL2]]|2.61|0.15|
|[[:human_genes:R:RHOH|RHOH]]|2.65|0.13|
|[[:human_genes:C:CEP192|CEP192]]|2.68|0.15|
|[[:human_genes:S:SHMT2|SHMT2]]|3.13|0.08|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.077|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.076|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|0.071|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.069|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.068|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp433|LJH685 50μM R08 exp433]]|0.066|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.066|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.065|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|0.064|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.063|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.063|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.062|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.059|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.057|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.057|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.056|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|0.056|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|0.056|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.056|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.055|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.054|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.053|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.053|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|0.052|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.051|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.051|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.051|<button type="primary" size="small" modal="27">View</button>|
</modal>


<modal id="1" size="lg" title="B02 10μM R08 exp453  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp453_vs_exp483.png?nolink |}}
</modal>

<modal id="2" size="lg" title="B02 10μM R08 exp453  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp453_vs_exp525.png?nolink |}}
</modal>

<modal id="3" size="lg" title="B02 10μM R08 exp453  vs  Trametinib 10μM R02 exp83">
{{:chemogenomics:comparison_plots:exp453_vs_exp83.png?nolink |}}
</modal>

<modal id="4" size="lg" title="B02 10μM R08 exp453  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp453_vs_exp498.png?nolink |}}
</modal>

<modal id="5" size="lg" title="B02 10μM R08 exp453  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp453_vs_exp508.png?nolink |}}
</modal>

<modal id="6" size="lg" title="B02 10μM R08 exp453  vs  LJH685 50μM R08 exp433">
{{:chemogenomics:comparison_plots:exp433_vs_exp453.png?nolink |}}
</modal>

<modal id="7" size="lg" title="B02 10μM R08 exp453  vs  Bisphenol F 50μM R08 exp457">
{{:chemogenomics:comparison_plots:exp453_vs_exp457.png?nolink |}}
</modal>

<modal id="8" size="lg" title="B02 10μM R08 exp453  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp359_vs_exp453.png?nolink |}}
</modal>

<modal id="9" size="lg" title="B02 10μM R08 exp453  vs  Benzoate 10000μM R08 exp455">
{{:chemogenomics:comparison_plots:exp453_vs_exp455.png?nolink |}}
</modal>

<modal id="10" size="lg" title="B02 10μM R08 exp453  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp442_vs_exp453.png?nolink |}}
</modal>

<modal id="11" size="lg" title="B02 10μM R08 exp453  vs  Hydroxychloroquine 30μM R08 exp490">
{{:chemogenomics:comparison_plots:exp453_vs_exp490.png?nolink |}}
</modal>

<modal id="12" size="lg" title="B02 10μM R08 exp453  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp453_vs_exp530.png?nolink |}}
</modal>

<modal id="13" size="lg" title="B02 10μM R08 exp453  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp233_vs_exp453.png?nolink |}}
</modal>

<modal id="14" size="lg" title="B02 10μM R08 exp453  vs  Chloroquine 32μM R08 exp470">
{{:chemogenomics:comparison_plots:exp453_vs_exp470.png?nolink |}}
</modal>

<modal id="15" size="lg" title="B02 10μM R08 exp453  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp453_vs_exp526.png?nolink |}}
</modal>

<modal id="16" size="lg" title="B02 10μM R08 exp453  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp453.png?nolink |}}
</modal>

<modal id="17" size="lg" title="B02 10μM R08 exp453  vs  UM0011500 5μM R05 exp245">
{{:chemogenomics:comparison_plots:exp245_vs_exp453.png?nolink |}}
</modal>

<modal id="18" size="lg" title="B02 10μM R08 exp453  vs  NN-Diethyl-meta-toluamide 500μM R08 exp438">
{{:chemogenomics:comparison_plots:exp438_vs_exp453.png?nolink |}}
</modal>

<modal id="19" size="lg" title="B02 10μM R08 exp453  vs  BS-181 20μM R08 exp461">
{{:chemogenomics:comparison_plots:exp453_vs_exp461.png?nolink |}}
</modal>

<modal id="20" size="lg" title="B02 10μM R08 exp453  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp453_vs_exp538.png?nolink |}}
</modal>

<modal id="21" size="lg" title="B02 10μM R08 exp453  vs  CAY10603 0.55μM R08 exp467">
{{:chemogenomics:comparison_plots:exp453_vs_exp467.png?nolink |}}
</modal>

<modal id="22" size="lg" title="B02 10μM R08 exp453  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp453.png?nolink |}}
</modal>

<modal id="23" size="lg" title="B02 10μM R08 exp453  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp453.png?nolink |}}
</modal>

<modal id="24" size="lg" title="B02 10μM R08 exp453  vs  Nicotine 3000μM R08 exp510">
{{:chemogenomics:comparison_plots:exp453_vs_exp510.png?nolink |}}
</modal>

<modal id="25" size="lg" title="B02 10μM R08 exp453  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp453.png?nolink |}}
</modal>

<modal id="26" size="lg" title="B02 10μM R08 exp453  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp453_vs_exp535.png?nolink |}}
</modal>

<modal id="27" size="lg" title="B02 10μM R08 exp453  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp453_vs_exp520.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>