TMED10 [The Human Chemical-Genetic Interaction Map Project]

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======= TMED10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMED10
  * **<color #00a2e8>Official Name</color>**: transmembrane p24 trafficking protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10972|10972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49755|P49755]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMED10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMED10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605406|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EMP24 GP25L|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI-coated vesicle budding|
|COPI coating of Golgi vesicle|
|Golgi transport vesicle coating|
|gamma-secretase complex|
|COPI-coated vesicle|
|zymogen granule membrane|
|trans-Golgi network transport vesicle|
|vesicle cargo loading|
|regulation of amyloid-beta formation|
|regulation of amyloid precursor protein catabolic process|
|COPII-coated ER to Golgi transport vesicle|
|ER to Golgi transport vesicle membrane|
|syntaxin binding|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|cis-Golgi network|
|vesicle coating|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment|
|Golgi vesicle budding|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle targeting|
|transport vesicle|
|vesicle budding from membrane|
|secretory granule membrane|
|melanosome|
|response to alkaloid|
|Golgi organization|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein-containing complex binding|
|kidney development|
|renal system development|
|vesicle organization|
|urogenital system development|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of cellular amide metabolic process|
|endomembrane system organization|
|protein complex oligomerization|
|organelle localization|
|Golgi membrane|
|regulated exocytosis|
|exocytosis|
|membrane organization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|response to nitrogen compound|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.59|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.34|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.17|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.16|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.13|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.13|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.04|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.01|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.97|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.91|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.85|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.82|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.8|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.8|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.79|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.75|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.71|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.7|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.76|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.79|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.88|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.95|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.02|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.04|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.07|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.14|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.14|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.18|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.26|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.27|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.27|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.66|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.69|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.92|
|[[:results:exp539|42°C R08 exp539]]|3.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmed2|TMED2]]|0.611|
|[[:human genes:d:dnajc3|DNAJC3]]|0.556|
|[[:human genes:a:alg5|ALG5]]|0.55|
|[[:human genes:m:manf|MANF]]|0.524|
|[[:human genes:a:alg6|ALG6]]|0.514|
|[[:human genes:u:ube2g2|UBE2G2]]|0.513|
|[[:human genes:c:c1orf27|C1orf27]]|0.509|
|[[:human genes:t:tmem41b|TMEM41B]]|0.509|
|[[:human genes:s:sec63|SEC63]]|0.489|
|[[:human genes:c:ccdc101|CCDC101]]|0.485|
|[[:human genes:p:pmm2|PMM2]]|0.478|
|[[:human genes:u:ufc1|UFC1]]|0.476|
|[[:human genes:u:ube2j1|UBE2J1]]|0.476|
|[[:human genes:u:uba5|UBA5]]|0.475|
|[[:human genes:d:dpagt1|DPAGT1]]|0.47|
|[[:human genes:e:eny2|ENY2]]|0.468|
|[[:human genes:s:sec62|SEC62]]|0.466|
|[[:human genes:r:rptor|RPTOR]]|0.463|
|[[:human genes:d:dnajb11|DNAJB11]]|0.462|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.461|
|[[:human genes:k:kcmf1|KCMF1]]|0.458|
|[[:human genes:a:atp5j|ATP5J]]|0.455|
|[[:human genes:a:alg1|ALG1]]|0.453|
|[[:human genes:s:stt3a|STT3A]]|0.451|
|[[:human genes:u:uso1|USO1]]|0.451|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.45|
|[[:human genes:d:derl1|DERL1]]|0.45|
|[[:human genes:g:gfpt1|GFPT1]]|0.45|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.449|
|[[:human genes:l:lsmd1|LSMD1]]|0.446|
|[[:human genes:u:uap1|UAP1]]|0.446|
|[[:human genes:d:dpf2|DPF2]]|0.446|
|[[:human genes:r:rnmt|RNMT]]|0.442|
|[[:human genes:d:dolk|DOLK]]|0.44|
|[[:human genes:p:pelo|PELO]]|0.439|
|[[:human genes:u:ufsp2|UFSP2]]|0.437|
|[[:human genes:s:srp14|SRP14]]|0.436|
|[[:human genes:a:atp5o|ATP5O]]|0.433|
|[[:human genes:t:timm13|TIMM13]]|0.433|
|[[:human genes:u:ufm1|UFM1]]|0.432|
|[[:human genes:u:ube2k|UBE2K]]|0.432|
|[[:human genes:f:fli1|FLI1]]|0.429|
|[[:human genes:e:eif4e|EIF4E]]|0.429|
|[[:human genes:t:triap1|TRIAP1]]|0.428|
|[[:human genes:m:med16|MED16]]|0.426|
|[[:human genes:m:mbtps2|MBTPS2]]|0.424|
|[[:human genes:s:sec61b|SEC61B]]|0.424|
|[[:human genes:g:gmppb|GMPPB]]|0.422|
|[[:human genes:t:thg1l|THG1L]]|0.42|
|[[:human genes:v:vmp1|VMP1]]|0.42|
|[[:human genes:w:wdr24|WDR24]]|0.412|
|[[:human genes:c:cbfb|CBFB]]|0.412|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.411|
|[[:human genes:d:derl2|DERL2]]|0.411|
|[[:human genes:r:rtcb|RTCB]]|0.41|
|[[:human genes:x:xpo6|XPO6]]|0.408|
|[[:human genes:t:trmt10a|TRMT10A]]|0.406|
|[[:human genes:p:plaa|PLAA]]|0.403|
|[[:human genes:a:aars|AARS]]|0.401|
|[[:human genes:a:atp5a1|ATP5A1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMED10 Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>