UGCG

Entrez Summary: N/A
UniProt Summary: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a “flippase”. {ECO:0000269|PubMed:8643456}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dihydroceramide glucosyltransferase activity
ceramide glucosyltransferase activity
glucosylceramide biosynthetic process
cornified envelope assembly
glycosylceramide biosynthetic process
glucosylceramide metabolic process
leptin-mediated signaling pathway
intestinal lipid absorption
cellular response to leptin stimulus
glycosylceramide metabolic process
response to leptin
establishment of skin barrier
glycosphingolipid biosynthetic process
regulation of water loss via skin
intestinal absorption
membrane assembly
membrane biogenesis
ceramide biosynthetic process
glycosphingolipid metabolic process
glycolipid biosynthetic process
multicellular organismal water homeostasis
water homeostasis
digestive system process
ceramide metabolic process
protein lipidation
lipoprotein biosynthetic process
sphingolipid biosynthetic process
plasma membrane organization
glycolipid metabolic process
liposaccharide metabolic process
digestion
lipoprotein metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
keratinocyte differentiation
lipid transport
epidermal cell differentiation
lipid localization
multicellular organismal homeostasis