UGCG [The Human Chemical-Genetic Interaction Map Project]

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======= UGCG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGCG
  * **<color #00a2e8>Official Name</color>**: UDP-glucose ceramide glucosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7357|7357]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16739|Q16739]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGCG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGCG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602874|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". {ECO:0000269|PubMed:8643456}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydroceramide glucosyltransferase activity|
|ceramide glucosyltransferase activity|
|glucosylceramide biosynthetic process|
|cornified envelope assembly|
|glycosylceramide biosynthetic process|
|glucosylceramide metabolic process|
|leptin-mediated signaling pathway|
|intestinal lipid absorption|
|cellular response to leptin stimulus|
|glycosylceramide metabolic process|
|response to leptin|
|establishment of skin barrier|
|glycosphingolipid biosynthetic process|
|regulation of water loss via skin|
|intestinal absorption|
|membrane assembly|
|membrane biogenesis|
|ceramide biosynthetic process|
|glycosphingolipid metabolic process|
|glycolipid biosynthetic process|
|multicellular organismal water homeostasis|
|water homeostasis|
|digestive system process|
|ceramide metabolic process|
|protein lipidation|
|lipoprotein biosynthetic process|
|sphingolipid biosynthetic process|
|plasma membrane organization|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|digestion|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|membrane lipid metabolic process|
|keratinocyte differentiation|
|lipid transport|
|epidermal cell differentiation|
|lipid localization|
|multicellular organismal homeostasis|
|skin development|
|epidermis development|
|endomembrane system organization|
|regulation of body fluid levels|
|amide biosynthetic process|
|lipid biosynthetic process|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|cellular amide metabolic process|
|neuron development|
|membrane organization|
|response to hormone|
|cellular lipid metabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.65|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.31|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.09|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.93|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.76|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.73|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9323
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGCG Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>