AP5B1

Entrez Summary: N/A
UniProt Summary: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 10μM R05 exp246	-3.3
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.87
Monensin 0.3μM R08 exp507	-2.44
UM0011500 5μM R05 exp245	-1.87
ETC-159 50μM R08 exp480	-1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AP-type membrane coat adaptor complex
endosomal transport
lysosomal membrane
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport