YPEL5 [The Human Chemical-Genetic Interaction Map Project]

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======= YPEL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YPEL5
  * **<color #00a2e8>Official Name</color>**: yippee like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51646|51646]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62699|P62699]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YPEL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YPEL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Yippee|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic spindle pole|
|tertiary granule lumen|
|ubiquitin ligase complex|
|ficolin-1-rich granule lumen|
|midbody|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cell population proliferation|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-4.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-4.8|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-4.39|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-3.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.63|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.57|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-3.46|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.38|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.36|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-3.26|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.99|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.85|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.8|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.66|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.55|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.54|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.53|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.48|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.41|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.4|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.34|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.25|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.22|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.21|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.19|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.17|
|[[:results:exp539|42°C R08 exp539]]|-2.16|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.12|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.09|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.08|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.01|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.01|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.99|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.97|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.96|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.95|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.9|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.89|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.87|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.85|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.8|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.78|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.76|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.76|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.76|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.76|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.71|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.71|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.7|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.78|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.91|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.93|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.97|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.16|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.19|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.28|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.34|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.4|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.52|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.54|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.57|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.83|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.91|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.94|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.04|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.13|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|3.16|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|3.37|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|3.48|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.64|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.85|
|[[:results:exp116|AICAR 240μM R03 exp116]]|5.57|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|5.81|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|6.34|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|6.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr26|WDR26]]|0.822|
|[[:human genes:u:ube2h|UBE2H]]|0.792|
|[[:human genes:m:maea|MAEA]]|0.683|
|[[:human genes:g:gid8|GID8]]|0.645|
|[[:human genes:m:memo1|MEMO1]]|0.587|
|[[:human genes:g:gsk3b|GSK3B]]|0.515|
|[[:human genes:f:fkbp1a|FKBP1A]]|0.493|
|[[:human genes:g:gskip|GSKIP]]|0.489|
|[[:human genes:c:cnot8|CNOT8]]|0.48|
|[[:human genes:o:otub1|OTUB1]]|0.479|
|[[:human genes:c:cdk8|CDK8]]|0.454|
|[[:human genes:a:anp32a|ANP32A]]|0.451|
|[[:human genes:k:kdm6a|KDM6A]]|0.438|
|[[:human genes:p:pou2af1|POU2AF1]]|0.426|
|[[:human genes:r:rmnd5a|RMND5A]]|0.424|
|[[:human genes:c:cnot2|CNOT2]]|0.419|
|[[:human genes:d:dnttip1|DNTTIP1]]|0.414|
|[[:human genes:f:fam122a|FAM122A]]|0.414|
|[[:human genes:g:glyr1|GLYR1]]|0.412|
|[[:human genes:u:uty|UTY]]|0.412|
|[[:human genes:t:tsc2|TSC2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 228/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|5/28|
|bone|8/26|
|breast|16/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|3/21|
|liver|8/20|
|lung|22/75|
|lymphocyte|2/16|
|ovary|9/26|
|pancreas|14/24|
|peripheral nervous system|6/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|7/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YPEL5 Expression in NALM6 Cells: 3.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>