BML-284 0.09μM R08 exp460 [The Human Chemical-Genetic Interaction Map Project]

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====== BML-284 0.09μM R08 exp460 ======
==== Mechanism of Action ====
Wnt agonist, GSK3-‘_ dependent, activates ‘_-catenin/TCF-dependent transcription
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Agonist
  * **<color #00a2e8>Class / Subclass 2:</color>** Gene Regulation / Transcription Activator



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Wnt Agonist%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 853220-52-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/11210285|11210285]]
    * **<color #00a2e8>IUPAC:</color>** %%4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
    * **<color #00a2e8>INCHI Key:</color>** FABQUVYDAXWUQP-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 350.4
    * **<color #00a2e8>Canonical SMILES:</color>** COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C19H18N4O3
{{:chemogenomics:structures:chem-0270.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-19987
    * **<color #00a2e8>Lot #:</color>** 20280
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C19H18N4O3 351.14517; found 351.14569
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** BML284
    * **<color #00a2e8>Min:</color>** 2.1177; **<color #00a2e8>Max:</color>** 99.1512
{{:chemogenomics:dose_response:dr_506.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.0660    |
| IC20  |0.0870    |
| IC30  |0.1046    |
| IC40  |0.1216    |
| IC50  |0.1396    |
| IC60  |0.1603    |
| IC70  |0.1863    |
| IC80  |0.2239    |
| IC90  |0.2952    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 90nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.1
    * **<color #00a2e8>Numbers of reads</color>**: 14681997


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|63/37|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/BML-284_0.09uM_Round-8_exp460.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='BML-284 0.09μM R08 exp460'>
{{:chemogenomics:cranks_plots:exp460.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:K:KIF18A|KIF18A]]|-4.14|0.00|
|[[:human_genes:A:ASPM|ASPM]]|-4.11|0.00|
|[[:human_genes:B:BRD1|BRD1]]|-3.96|0.00|
|[[:human_genes:M:MAPRE1|MAPRE1]]|-3.83|0.00|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-3.69|0.00|
|[[:human_genes:Q:QRICH1|QRICH1]]|-3.54|0.00|
|[[:human_genes:A:ARID4B|ARID4B]]|-3.52|0.00|
|[[:human_genes:M:MSI2|MSI2]]|-3.49|0.00|
|[[:human_genes:T:TCF4|TCF4]]|-3.42|0.00|
|[[:human_genes:P:PDS5B|PDS5B]]|-3.38|0.00|
|[[:human_genes:Y:YPEL5|YPEL5]]|-3.38|0.00|
|[[:human_genes:D:DLGAP5|DLGAP5]]|-3.37|0.00|
|[[:human_genes:K:KIF15|KIF15]]|-3.31|0.00|
|[[:human_genes:K:KIFC1|KIFC1]]|-3.30|0.00|
|[[:human_genes:T:TRIP13|TRIP13]]|-3.27|0.00|
|[[:human_genes:C:CNOT2|CNOT2]]|-3.23|0.00|
|[[:human_genes:E:ESCO2|ESCO2]]|-3.22|0.00|
|[[:human_genes:U:UBE4B|UBE4B]]|-3.11|0.00|
|[[:human_genes:P:PSME3|PSME3]]|-3.06|<0.01|
|[[:human_genes:K:KNTC1|KNTC1]]|-2.92|<0.01|
|[[:human_genes:T:TACC3|TACC3]]|-2.91|<0.01|
|[[:human_genes:V:VPS25|VPS25]]|-2.88|0.10|
|[[:human_genes:H:HSPA4|HSPA4]]|-2.87|<0.01|
|[[:human_genes:E:EDF1|EDF1]]|-2.87|<0.01|
|[[:human_genes:K:KATNB1|KATNB1]]|-2.77|<0.01|
|[[:human_genes:Z:ZWILCH|ZWILCH]]|-2.77|<0.01|
|[[:human_genes:F:FDPS|FDPS]]|-2.73|<0.01|
|[[:human_genes:R:RC3H1|RC3H1]]|-2.68|<0.01|
|[[:human_genes:S:SZT2|SZT2]]|-2.65|<0.01|
|[[:human_genes:V:VBP1|VBP1]]|-2.65|<0.01|
|[[:human_genes:P:PIGO|PIGO]]|2.47|0.06|
|[[:human_genes:M:MTA1|MTA1]]|2.47|0.03|
|[[:human_genes:V:VAPA|VAPA]]|2.51|0.01|
|[[:human_genes:Z:ZC3H7A|ZC3H7A]]|2.53|0.01|
|[[:human_genes:A:ASXL2|ASXL2]]|2.57|0.02|
|[[:human_genes:S:SRM|SRM]]|2.60|0.01|
|[[:human_genes:F:FKBP5|FKBP5]]|2.61|<0.01|
|[[:human_genes:O:OTUD5|OTUD5]]|2.66|0.03|
|[[:human_genes:S:SPOP|SPOP]]|2.67|<0.01|
|[[:human_genes:S:SRF|SRF]]|2.70|0.01|
|[[:human_genes:C:CBX3|CBX3]]|2.73|<0.01|
|[[:human_genes:M:MBTPS1|MBTPS1]]|2.79|0.02|
|[[:human_genes:S:SP3|SP3]]|2.96|<0.01|
|[[:human_genes:N:NUMA1|NUMA1]]|3.05|<0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|3.08|0.00|
|[[:human_genes:I:ID3|ID3]]|3.10|0.00|
|[[:human_genes:L:LCMT1|LCMT1]]|3.12|0.00|
|[[:human_genes:P:PPP6R3|PPP6R3]]|3.12|0.00|
|[[:human_genes:T:TP53BP1|TP53BP1]]|3.14|<0.01|
|[[:human_genes:N:NDE1|NDE1]]|3.14|0.00|
|[[:human_genes:A:ACTB|ACTB]]|3.20|0.00|
|[[:human_genes:K:KIF18B|KIF18B]]|3.29|0.00|
|[[:human_genes:U:USP28|USP28]]|3.31|0.00|
|[[:human_genes:A:ATAT1|ATAT1]]|3.50|0.00|
|[[:human_genes:K:KHDRBS1|KHDRBS1]]|3.58|0.00|
|[[:human_genes:Z:ZNF592|ZNF592]]|3.75|0.00|
|[[:human_genes:C:CCNF|CCNF]]|4.04|0.00|
|[[:human_genes:T:TMEM161B|TMEM161B]]|4.54|0.00|
|[[:human_genes:T:TP53|TP53]]|5.73|0.00|
|[[:human_genes:A:ATP1A1|ATP1A1]]|6.06|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|0.207|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.172|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.172|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|0.136|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|0.121|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.121|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|0.116|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.109|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.107|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.106|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|0.104|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|0.094|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|0.076|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|0.075|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.067|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.063|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|0.062|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.062|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.061|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|0.058|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.057|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.056|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.055|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.055|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.055|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|0.054|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|0.053|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.053|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.053|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.051|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.137|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|0.095|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|0.089|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|0.071|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.064|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.051|<button type="primary" size="small" modal="36">View</button>|
</modal>


<modal id="1" size="lg" title="BML-284 0.09μM R08 exp460  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp460.png?nolink |}}
</modal>

<modal id="2" size="lg" title="BML-284 0.09μM R08 exp460  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp460.png?nolink |}}
</modal>

<modal id="3" size="lg" title="BML-284 0.09μM R08 exp460  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp460_vs_exp59.png?nolink |}}
</modal>

<modal id="4" size="lg" title="BML-284 0.09μM R08 exp460  vs  Colchicine 0.009μM R05 exp215">
{{:chemogenomics:comparison_plots:exp215_vs_exp460.png?nolink |}}
</modal>

<modal id="5" size="lg" title="BML-284 0.09μM R08 exp460  vs  Demecolcine 0.03μM R05 exp228">
{{:chemogenomics:comparison_plots:exp228_vs_exp460.png?nolink |}}
</modal>

<modal id="6" size="lg" title="BML-284 0.09μM R08 exp460  vs  Combretastatin A4 0.002 to 0.003μM day4 R04 exp179">
{{:chemogenomics:comparison_plots:exp179_vs_exp460.png?nolink |}}
</modal>

<modal id="7" size="lg" title="BML-284 0.09μM R08 exp460  vs  Vincristine 0.0005μM R04 exp190">
{{:chemogenomics:comparison_plots:exp190_vs_exp460.png?nolink |}}
</modal>

<modal id="8" size="lg" title="BML-284 0.09μM R08 exp460  vs  Taxol 0.004μM R03 exp103">
{{:chemogenomics:comparison_plots:exp103_vs_exp460.png?nolink |}}
</modal>

<modal id="9" size="lg" title="BML-284 0.09μM R08 exp460  vs  BVD-523 15μM R02 exp67">
{{:chemogenomics:comparison_plots:exp460_vs_exp67.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BML-284 0.09μM R08 exp460  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp460_vs_exp517.png?nolink |}}
</modal>

<modal id="11" size="lg" title="BML-284 0.09μM R08 exp460  vs  Ixabepilone 0.004 to 0.005μM on day4 R04 exp184">
{{:chemogenomics:comparison_plots:exp184_vs_exp460.png?nolink |}}
</modal>

<modal id="12" size="lg" title="BML-284 0.09μM R08 exp460  vs  Vinblastine 0.002μM R01 exp60">
{{:chemogenomics:comparison_plots:exp460_vs_exp60.png?nolink |}}
</modal>

<modal id="13" size="lg" title="BML-284 0.09μM R08 exp460  vs  Epothilone-B 0.0015μM R05 exp231">
{{:chemogenomics:comparison_plots:exp231_vs_exp460.png?nolink |}}
</modal>

<modal id="14" size="lg" title="BML-284 0.09μM R08 exp460  vs  S-trityl-L-cysteine 0.5μM R05 exp243">
{{:chemogenomics:comparison_plots:exp243_vs_exp460.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BML-284 0.09μM R08 exp460  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp460_vs_exp502.png?nolink |}}
</modal>

<modal id="16" size="lg" title="BML-284 0.09μM R08 exp460  vs  Genistein 15μM R07 exp360">
{{:chemogenomics:comparison_plots:exp360_vs_exp460.png?nolink |}}
</modal>

<modal id="17" size="lg" title="BML-284 0.09μM R08 exp460  vs  UMK57 0.6μM R03 exp107">
{{:chemogenomics:comparison_plots:exp107_vs_exp460.png?nolink |}}
</modal>

<modal id="18" size="lg" title="BML-284 0.09μM R08 exp460  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp460.png?nolink |}}
</modal>

<modal id="19" size="lg" title="BML-284 0.09μM R08 exp460  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp460_vs_exp526.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BML-284 0.09μM R08 exp460  vs  HMS-I1 1μM R01 exp46">
{{:chemogenomics:comparison_plots:exp46_vs_exp460.png?nolink |}}
</modal>

<modal id="21" size="lg" title="BML-284 0.09μM R08 exp460  vs  LLY-283 2.6μM R06 exp290">
{{:chemogenomics:comparison_plots:exp290_vs_exp460.png?nolink |}}
</modal>

<modal id="22" size="lg" title="BML-284 0.09μM R08 exp460  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp460_vs_exp485.png?nolink |}}
</modal>

<modal id="23" size="lg" title="BML-284 0.09μM R08 exp460  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp460.png?nolink |}}
</modal>

<modal id="24" size="lg" title="BML-284 0.09μM R08 exp460  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp460_vs_exp525.png?nolink |}}
</modal>

<modal id="25" size="lg" title="BML-284 0.09μM R08 exp460  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp460.png?nolink |}}
</modal>

<modal id="26" size="lg" title="BML-284 0.09μM R08 exp460  vs  CoCl2 18μM R07 exp346">
{{:chemogenomics:comparison_plots:exp346_vs_exp460.png?nolink |}}
</modal>

<modal id="27" size="lg" title="BML-284 0.09μM R08 exp460  vs  Docetaxel 0.002μM R01 exp45">
{{:chemogenomics:comparison_plots:exp45_vs_exp460.png?nolink |}}
</modal>

<modal id="28" size="lg" title="BML-284 0.09μM R08 exp460  vs  Diepoxybutane 3μM R07 exp354">
{{:chemogenomics:comparison_plots:exp354_vs_exp460.png?nolink |}}
</modal>

<modal id="29" size="lg" title="BML-284 0.09μM R08 exp460  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp460_vs_exp500.png?nolink |}}
</modal>

<modal id="30" size="lg" title="BML-284 0.09μM R08 exp460  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp460.png?nolink |}}
</modal>

<modal id="31" size="lg" title="2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp312_vs_exp460.png?nolink |}}
</modal>

<modal id="32" size="lg" title="2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp311_vs_exp460.png?nolink |}}
</modal>

<modal id="33" size="lg" title="2-Methoxyestradiol 0.55μM R07 exp310  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp310_vs_exp460.png?nolink |}}
</modal>

<modal id="34" size="lg" title="BI-6727 0.0125μM R03 exp97  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp460_vs_exp97.png?nolink |}}
</modal>

<modal id="35" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp175_vs_exp460.png?nolink |}}
</modal>

<modal id="36" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp2_vs_exp460.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|kinetochore microtubule|95.22|KIF18A,KNTC1,ZWILCH|
|chromosome localization|30.07|KIF18A,MAPRE1,DLGAP5,KIFC1,KATNB1|
|regulation of sister chromatid segregation|27.74|DLGAP5,TRIP13,KNTC1,TACC3,ZWILCH|
|mitotic sister chromatid segregation|25.02|KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1|
|sister chromatid segregation|24.31|KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1|
|spindle pole|23.53|ASPM,MAPRE1,YPEL5,DLGAP5,KNTC1,TACC3,KATNB1|
|mitotic spindle|22.47|KIF18A,ASPM,MAPRE1,YPEL5,DLGAP5,KIFC1,TACC3|
|mitotic nuclear division|20.90|KIF18A,MAPRE1,DLGAP5,KIFC1,KNTC1,KATNB1|
|nuclear chromosome segregation|20.78|KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1|
|chromosome segregation|15.68|KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,KATNB1|
|spindle|15.14|KIF18A,ASPM,MAPRE1,YPEL5,DLGAP5,KIF15,KIFC1,KNTC1,TACC3,KATNB1,ZWILCH|
|nuclear division|15.04|KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1|
|organelle fission|13.89|KIF18A,ASPM,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,KATNB1|
|chromosome organization|11.69|KIF18A,MAPRE1,PDS5B,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,KATNB1|
|microtubule|10.53|KIF18A,ASPM,MAPRE1,KIF15,KIFC1,KNTC1,KATNB1,ZWILCH|
|mitotic cell cycle process|9.97|KIF18A,MAPRE1,DLGAP5,KIFC1,TRIP13,KNTC1,TACC3,KATNB1,ZWILCH|
|mitotic cell cycle|9.52|KIF18A,MAPRE1,DLGAP5,KIF15,KIFC1,TRIP13,KNTC1,TACC3,KATNB1,ZWILCH|
|cell division|9.03|ASPM,MAPRE1,PDS5B,KIFC1,KNTC1,TACC3,KATNB1,ZWILCH|
|cell cycle process|7.86|KIF18A,ASPM,MAPRE1,PDS5B,DLGAP5,KIFC1,TRIP13,ESCO2,KNTC1,TACC3,KATNB1,ZWILCH|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitotic cell cycle process|8.56|TP53,CCNF,KHDRBS1,KIF18B,NDE1,LCMT1,NUMA1,MBTPS1|
|mitotic cell cycle|7.36|TP53,CCNF,KHDRBS1,KIF18B,NDE1,LCMT1,NUMA1,MBTPS1|
</modal>