FKBP5
Gene Information
- Official Symbol: FKBP5
- Official Name: FKBP prolyl isomerase 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 2289
- UniProt: Q13451
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].
- UniProt Summary: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14781
- Expression level (log2 read counts): 6.89
FKBP5 Expression in NALM6 Cells: 6.89
