C11orf85

Entrez Summary: N/A
UniProt Summary: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

meiotic telomere tethering at nuclear periphery
chromosome attachment to the nuclear envelope
meiotic attachment of telomere to nuclear envelope
telomere tethering at nuclear periphery
meiotic telomere clustering
chromosome localization to nuclear envelope involved in homologous chromosome segregation
telomere localization
integral component of nuclear inner membrane
synapsis
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
establishment of chromosome localization
chromosome localization
meiotic chromosome segregation
meiosis I
nuclear chromosome, telomeric region
meiosis I cell cycle process
meiotic nuclear division
meiotic cell cycle process
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
organelle fission
establishment of organelle localization
organelle localization
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
DNA binding
establishment of localization in cell