C11orf85 [The Human Chemical-Genetic Interaction Map Project]

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======= C11orf85 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAJIN
  * **<color #00a2e8>Official Name</color>**: membrane anchored junction protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283129|283129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3KP22|Q3KP22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C11orf85&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C11orf85|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic telomere tethering at nuclear periphery|
|chromosome attachment to the nuclear envelope|
|meiotic attachment of telomere to nuclear envelope|
|telomere tethering at nuclear periphery|
|meiotic telomere clustering|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|telomere localization|
|integral component of nuclear inner membrane|
|synapsis|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|meiotic chromosome segregation|
|meiosis I|
|nuclear chromosome, telomeric region|
|meiosis I cell cycle process|
|meiotic nuclear division|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|organelle localization|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C11ORF85 Expression in NALM6 Cells: -2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>