GPR55

Gene Information

Official Symbol: GPR55
Official Name: G protein-coupled receptor 55
Aliases and Previous Symbols: N/A
Entrez ID: 9290
UniProt: Q9Y2T6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013].
UniProt Summary: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. {ECO:0000250, ECO:0000269|PubMed:19805329}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.74
Cyclosporin-A 3μM R07 exp348	1.9
A-769662 20μM R07 exp331	1.97
Docosahexaenoic-acid 50μM R07 exp356	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5287
Expression level (log2 read counts): 1.11

Expression Distribution

cannabinoid receptor activity
cannabinoid signaling pathway
bone resorption
negative regulation of osteoclast differentiation
positive regulation of Rho protein signal transduction
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of phospholipase C activity
negative regulation of myeloid leukocyte differentiation
regulation of phospholipase C activity
bone remodeling
positive regulation of phospholipase activity
positive regulation of Ras protein signal transduction
regulation of osteoclast differentiation
positive regulation of small GTPase mediated signal transduction
positive regulation of lipase activity
regulation of phospholipase activity
negative regulation of myeloid cell differentiation
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of lipase activity
negative regulation of leukocyte differentiation
tissue remodeling
regulation of myeloid leukocyte differentiation
negative regulation of hemopoiesis
regulation of Rho protein signal transduction
tissue homeostasis
positive regulation of ERK1 and ERK2 cascade
regulation of myeloid cell differentiation
regulation of Ras protein signal transduction
regulation of leukocyte differentiation
positive regulation of cytosolic calcium ion concentration
regulation of ERK1 and ERK2 cascade
multicellular organismal homeostasis
regulation of cytosolic calcium ion concentration
anatomical structure homeostasis
regulation of small GTPase mediated signal transduction
cellular calcium ion homeostasis
negative regulation of immune system process
calcium ion homeostasis
regulation of hemopoiesis