LMF1

Entrez Summary: The protein encoded by this gene resides in the endoplasmic reticulum, and is involved in the maturation and transport of lipoprotein lipase through the secretory pathway. Mutations in this gene are associated with combined lipase deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL. {ECO:0000250|UniProtKB:Q3U3R4, ECO:0000269|PubMed:24909692}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein glycosylation in Golgi
chylomicron remnant clearance
triglyceride-rich lipoprotein particle clearance
positive regulation of lipoprotein lipase activity
positive regulation of triglyceride lipase activity
regulation of lipoprotein lipase activity
regulation of triglyceride metabolic process
plasma lipoprotein particle clearance
regulation of cholesterol metabolic process
positive regulation of lipase activity
regulation of plasma lipoprotein particle levels
triglyceride metabolic process
regulation of lipase activity
acylglycerol metabolic process
neutral lipid metabolic process
regulation of steroid metabolic process
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
endoplasmic reticulum to Golgi vesicle-mediated transport
protein maturation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
Golgi vesicle transport
glycerolipid metabolic process
glycoprotein metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
carbohydrate derivative biosynthetic process
positive regulation of hydrolase activity
endoplasmic reticulum membrane
cellular lipid metabolic process
Golgi apparatus
secretion by cell
carbohydrate derivative metabolic process
export from cell
secretion