IL20

Gene Information

Official Symbol: IL20
Official Name: interleukin 20
Aliases and Previous Symbols: N/A
Entrez ID: 50604
UniProt: Q9NYY1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. {ECO:0000269|PubMed:16511554}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18228
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Taxol 0.002μM R01 exp54	-2.11
Menadione 5μM R06 exp292	-1.72
HMS-I1 10μM R06 exp256	-1.71

interleukin-20 receptor binding
interleukin-22 receptor binding
positive regulation of keratinocyte differentiation
positive regulation of epidermal cell differentiation
positive regulation of osteoclast differentiation
positive regulation of epidermis development
regulation of keratinocyte differentiation
positive regulation of myeloid leukocyte differentiation
positive regulation of epithelial cell differentiation
regulation of epidermal cell differentiation
regulation of osteoclast differentiation
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
regulation of epidermis development
positive regulation of receptor signaling pathway via STAT
positive regulation of myeloid cell differentiation
regulation of myeloid leukocyte differentiation
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
regulation of epithelial cell differentiation
positive regulation of leukocyte differentiation
cytokine activity
positive regulation of hemopoiesis
positive regulation of peptidyl-tyrosine phosphorylation
regulation of myeloid cell differentiation
regulation of peptidyl-tyrosine phosphorylation
regulation of leukocyte differentiation
regulation of inflammatory response
regulation of hemopoiesis
cytokine-mediated signaling pathway
regulation of defense response
positive regulation of cell differentiation
cellular response to cytokine stimulus
positive regulation of protein phosphorylation
positive regulation of phosphorylation
regulation of response to external stimulus
response to cytokine
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process