MYO9A
Gene Information
- Official Symbol: MYO9A
- Official Name: myosin IXA
- Aliases and Previous Symbols: N/A
- Entrez ID: 4649
- UniProt: B2RTY4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RA |
| RhoGAP |
| Myosin head |
GO Terms
| unconventional myosin complex |
| regulation of neuron projection arborization |
| establishment of epithelial cell apical/basal polarity |
| polarized epithelial cell differentiation |
| establishment of apical/basal cell polarity |
| establishment of monopolar cell polarity |
| establishment or maintenance of monopolar cell polarity |
| axonal growth cone |
| establishment of epithelial cell polarity |
| morphogenesis of a polarized epithelium |
| motor activity |
| establishment or maintenance of epithelial cell apical/basal polarity |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| establishment of cell polarity |
| cell junction assembly |
| establishment or maintenance of cell polarity |
| cell junction organization |
| visual perception |
| sensory perception of light stimulus |
| synapse |
| actin binding |
| GTPase activator activity |
| regulation of small GTPase mediated signal transduction |
| positive regulation of GTPase activity |
| morphogenesis of an epithelium |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| cell junction |
| tissue morphogenesis |
| regulation of neuron differentiation |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| positive regulation of hydrolase activity |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| sensory perception |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| regulation of hydrolase activity |
| nervous system process |
| positive regulation of catalytic activity |
| ATP binding |
| generation of neurons |
| neurogenesis |
| intracellular signal transduction |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bortezomib 0.05μM R00 exp7 | -2.22 |
| TRAIL 5ng/ml R00 exp35 | 1.84 |
| TRAIL 50ng/ml R00 exp36 | 1.85 |
| UM131593 0.1μM R01 exp58 | 2.23 |
| Taxol 0.002μM R01 exp54 | 2.36 |
| Docetaxel 0.002μM R01 exp45 | 2.64 |
| Nifuroxazide 1μM R01 exp51 | 3.46 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3624
- Expression level (log2 read counts): 6.15
Expression Distribution
MYO9A Expression in NALM6 Cells: 6.15
