YEATS2

Entrez Summary: Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017].
UniProt Summary: Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-2536 0.001μM R01 exp41	-2.26
Lapatinib 5μM R01 exp47	-2.25
Taxol 0.002μM R01 exp54	-2.2
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.82
Ribavirin 10μM R01 exp52	-1.81
Monensin 0.3μM R08 exp507	1.73
MLN-4924 0.2μM R00 exp21	1.74
GSK626616 14μM R08 exp485	1.83
QNZ 0.01μM R05 exp241	1.88
Arsenic trioxide 60μM R08 exp449	1.92
Amiloride 100μM R08 exp447	2.04
Aphidicolin 0.4μM R08 exp440	2.15
MS023 7μM R03 exp135	2.97
Actinomycin-D 0.001μM R00 exp3	3.08

Global Fraction of Cell Lines Where Essential: 52/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	3/25
breast	3/33
central nervous system	5/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	1/1
gastric	0/15
kidney	1/21
liver	1/20
lung	6/75
lymphocyte	0/14
ovary	3/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	6/29
uterus	1/5

Expression Distribution

modification-dependent protein binding
Ada2/Gcn5/Ada3 transcription activator complex
TBP-class protein binding
histone H3 acetylation
mitotic spindle
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
histone binding
protein acetylation
protein acylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin organization
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression