NOP2

Entrez Summary: N/A
UniProt Summary: Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). {ECO:0000269|PubMed:24120868, ECO:0000305, ECO:0000305|PubMed:23913415}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-2.72
Aminopterin 0.005μM R07 exp335	1.72
Mubritinib 0.2μM R01 exp48	1.74
Celastrol 0.12μM R05 exp225	1.77
Vinblastine 0.002μM R01 exp60	1.78
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.81
WYE-354 6μM R02 exp90	1.88
Nifuroxazide 1μM R01 exp51	1.94
UM131593 0.1μM R01 exp58	1.95
BI-6727 0.001μM R01 exp42	2.07
Ibrutinib 10μM R08 exp442	2.1
ML-792 0.2μM R08 exp505	2.13
YM155 0.0002μM R01 exp61	2.27
CCCP 0.1μM R00 exp10	2.28
2-Methoxyestradiol 0.2μM R01 exp40	2.48
Taxol 0.002μM R01 exp54	2.56
Docetaxel 0.002μM R01 exp45	2.64
Deguelin 0.15μM R05 exp209	2.69
NFN1 0.1μM R01 exp49	3.19

Global Fraction of Cell Lines Where Essential: 688/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	25/28
blood	26/28
bone	22/26
breast	29/33
central nervous system	55/56
cervix	4/4
colorectal	13/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	19/21
liver	19/20
lung	71/75
lymphocyte	15/16
ovary	26/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	11/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	5/5

Expression Distribution

P120R
Nol1 Nop2 Fmu

rRNA (cytosine-C5-)-methyltransferase activity
rRNA base methylation
rRNA methylation
ribosomal large subunit assembly
rRNA modification
ribosome assembly
ribosomal large subunit biogenesis
RNA methylation
RNA modification
regulation of signal transduction by p53 class mediator
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
macromolecule methylation
ribosome biogenesis
methylation
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organelle assembly
cellular protein-containing complex assembly
nucleolus
RNA processing
positive regulation of cell population proliferation
RNA binding
protein-containing complex assembly
regulation of cell population proliferation
RNA metabolic process
regulation of intracellular signal transduction
protein-containing complex subunit organization
gene expression