RPL15 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL15
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6138|6138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61313|P61313]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604174|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L15e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|cadherin binding|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.8|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.7|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.78|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.97|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.505|
|[[:human genes:z:znf622|ZNF622]]|0.48|
|[[:human genes:p:polr2j3|POLR2J3]]|0.474|
|[[:human genes:p:prim1|PRIM1]]|0.452|
|[[:human genes:r:rrp15|RRP15]]|0.45|
|[[:human genes:r:rpl17|RPL17]]|0.438|
|[[:human genes:n:nol12|NOL12]]|0.437|
|[[:human genes:r:rpl6|RPL6]]|0.427|
|[[:human genes:p:psmb4|PSMB4]]|0.425|
|[[:human genes:d:ddx56|DDX56]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.415|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.415|
|[[:human genes:g:gga3|GGA3]]|0.408|
|[[:human genes:l:lrr1|LRR1]]|0.407|
|[[:human genes:n:npipb5|NPIPB5]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 610/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|26/28|
|bone|22/26|
|breast|22/33|
|central nervous system|50/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|20/21|
|liver|17/20|
|lung|58/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1041
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL15 Expression in NALM6 Cells: 9.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>