BTAF1

Entrez Summary: N/A
UniProt Summary: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.75
Thimerosal 0.85μM R08 exp529	1.84
MLN-4924 0.2μM R00 exp21	1.88
CI-1040 9.5μM R08 exp472	1.98
Rotenone 20μM R00 exp34	2.07
Senexin-A 25μM R07 exp400	2.17
UM131593 0.2μM R03 exp106	2.18
Deferoxamine 11μM R07 exp350	2.45
Doxorubicin 0.02μM R08 exp478	2.72
5-Fluorouracil 20μM R00 exp2	3.21
Actinomycin-D 0.001μM R00 exp3	3.7
TRAIL 50ng/ml R00 exp36	3.97
TRAIL 5ng/ml R00 exp35	4.43

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of chromatin binding
regulation of chromatin binding
helicase activity
negative regulation of binding
regulation of binding
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
negative regulation of molecular function
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
ATP binding
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression