NAA35

Entrez Summary: N/A
UniProt Summary: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. {ECO:0000269|PubMed:19398576}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trichostatin-A 0.06μM R07 exp415	-1.82
BI-D1870 3.15μM R02 exp66	-1.7
Nicotinamide Riboside 100μM R03 exp139	1.82
MLN-4924 0.2μM R00 exp21	2
TRAIL 5ng/ml R00 exp35	2.32

Global Fraction of Cell Lines Where Essential: 158/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	4/28
bone	2/26
breast	10/33
central nervous system	4/56
cervix	2/4
colorectal	7/17
esophagus	2/13
fibroblast	1/1
gastric	2/16
kidney	4/21
liver	3/20
lung	28/75
lymphocyte	4/16
ovary	4/26
pancreas	5/24
peripheral nervous system	5/16
plasma cell	0/15
prostate	1/1
skin	4/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	5/29
uterus	0/5

Expression Distribution

NatC complex
smooth muscle cell proliferation
N-terminal peptidyl-methionine acetylation
peptide alpha-N-acetyltransferase activity
peptidyl-methionine modification
N-terminal protein amino acid acetylation
muscle cell proliferation
N-terminal protein amino acid modification
polysome
protein acetylation
protein acylation
protein maturation
cell population proliferation
peptidyl-amino acid modification
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
gene expression