GOLGA3

Entrez Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010].
UniProt Summary: Golgi auto-antigen; probably involved in maintaining Golgi structure.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 1000μM R03 exp101	-1.99
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.01

extrinsic component of Golgi membrane
Golgi transport complex
intra-Golgi vesicle-mediated transport
Golgi cisterna membrane
cadherin binding
Golgi vesicle transport
spermatogenesis
male gamete generation
Golgi membrane
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
nucleolus
Golgi apparatus
multi-organism reproductive process
reproductive process
reproduction
vesicle-mediated transport
membrane