SEPT12

Entrez Summary: N/A
UniProt Summary: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000269|PubMed:24213608, ECO:0000269|PubMed:25588830, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Septin
AIG1

sperm annulus
septin ring
septin complex
cleavage furrow
stress fiber
flagellated sperm motility
sperm motility
GDP binding
phosphatidylinositol binding
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
cytoskeleton-dependent cytokinesis
cytokinesis
spindle
microtubule cytoskeleton
midbody
GTPase activity
GTP binding
cell division
spermatogenesis
male gamete generation
gamete generation
perinuclear region of cytoplasm
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
protein homodimerization activity
multi-organism reproductive process
cell cycle process
identical protein binding
localization of cell
cell motility
locomotion
cell cycle
reproductive process
reproduction
movement of cell or subcellular component