GSS

Entrez Summary: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thimerosal 0.85μM R08 exp529	-3.6
MKC9989 10μM R03 exp133	-2.69
Arsenic trioxide 60μM R08 exp449	-2.39
Arsenate 40μM R06 exp264	-2.34
Dynasore 10μM R04 exp180	-2.25
Docosahexaenoic-acid 50μM R07 exp356	-2.18
3-Bromopyruvate 7μM R04 exp175	-2.05
QNZ 0.01μM R05 exp241	-2.05
Apcin 25μM plus proTAME 2μM R04 exp177	-2.04
Epigallocatechin gallate 20μM R05 exp230	-2.02
Isonicotinamide 500μM R03 exp129	-1.99
NFN1 0.4μM R03 exp99	-1.97
Menadione 5μM R06 exp292	-1.96
proTAME 5μM R04 exp187	-1.93
JQ1 0.01μM R03 exp130	-1.92
Benzoate 10000μM R08 exp455	-1.9
VE-822 0.04μM R06 exp300	-1.83
Quinacrine 2.5μM R03 exp146	-1.75
Etoposide 0.1μM R05 exp198	-1.74
YM155 0.001μM R08 exp432	-1.72
INK128 0.2μM R02 exp70	1.7
UM0129480 7μM R02 exp85	1.74
Lapatinib 5μM R01 exp47	1.8
Pyronaridine 1μM R06 exp295	1.86
Thapsigargin 0.005μM R07 exp407	2.71
RK-33 8μM R08 exp518	4.29

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GSH synthase
GSH synth ATP

glutathione synthase activity
glutathione binding
glycine binding
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
cellular modified amino acid biosynthetic process
glutathione metabolic process
response to cadmium ion
response to amino acid
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
cofactor biosynthetic process
magnesium ion binding
response to tumor necrosis factor
aging
response to xenobiotic stimulus
cellular amino acid metabolic process
response to acid chemical
sulfur compound metabolic process
response to metal ion
response to oxidative stress
peptide biosynthetic process
cofactor metabolic process
response to nutrient levels
amide biosynthetic process
peptide metabolic process
response to extracellular stimulus
response to inorganic substance
cellular amide metabolic process
protein homodimerization activity
carboxylic acid metabolic process
response to organonitrogen compound
oxoacid metabolic process
organic acid metabolic process
identical protein binding
response to nitrogen compound
response to cytokine
organonitrogen compound biosynthetic process
ATP binding
response to oxygen-containing compound