GSS [The Human Chemical-Genetic Interaction Map Project]

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======= GSS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSS
  * **<color #00a2e8>Official Name</color>**: glutathione synthetase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2937|2937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48637|P48637]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601002|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GSH synthase|
|GSH synth ATP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutathione synthase activity|
|glutathione binding|
|glycine binding|
|glutathione biosynthetic process|
|nonribosomal peptide biosynthetic process|
|cellular modified amino acid biosynthetic process|
|glutathione metabolic process|
|response to cadmium ion|
|response to amino acid|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|cofactor biosynthetic process|
|magnesium ion binding|
|response to tumor necrosis factor|
|aging|
|response to xenobiotic stimulus|
|cellular amino acid metabolic process|
|response to acid chemical|
|sulfur compound metabolic process|
|response to metal ion|
|response to oxidative stress|
|peptide biosynthetic process|
|cofactor metabolic process|
|response to nutrient levels|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|organonitrogen compound biosynthetic process|
|ATP binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.6|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.69|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.39|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.34|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.25|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.18|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.05|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.05|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.04|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.02|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.99|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.97|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.96|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.93|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.92|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.9|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.83|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.75|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.74|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.72|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.7|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.74|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.8|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.86|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.71|
|[[:results:exp518|RK-33 8μM R08 exp518]]|4.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gclm|GCLM]]|0.751|
|[[:human genes:g:gclc|GCLC]]|0.623|
|[[:human genes:o:osgin2|OSGIN2]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSS Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>