HIP1

Gene Information

Official Symbol: HIP1
Official Name: huntingtin interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 3092
UniProt: O00291
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9095
Expression level (log2 read counts): 5.14

Expression Distribution

Screen	Score
Demecolcine 0.03μM R05 exp228	-1.96
A-196 10μM R03 exp114	-1.9
Quinacrine 2.5μM R03 exp146	-1.89
NFN1 0.4μM R03 exp99	2.27

I LWEQ
ENTH
ANTH

positive regulation of platelet-derived growth factor receptor-beta signaling pathway
extrinsic component of postsynaptic membrane
extrinsic component of presynaptic membrane
positive regulation of platelet-derived growth factor receptor signaling pathway
glutamate receptor binding
clathrin light chain binding
regulation of platelet-derived growth factor receptor-beta signaling pathway
AP-2 adaptor complex binding
clathrin adaptor activity
AP-2 adaptor complex
actin cortical patch
clathrin coat assembly
regulation of platelet-derived growth factor receptor signaling pathway
clathrin-dependent endocytosis
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
positive regulation of epidermal growth factor receptor signaling pathway
epidermal growth factor receptor binding
positive regulation of ERBB signaling pathway
neurotransmitter receptor transport
clathrin binding
phosphatidylinositol-3-phosphate binding
positive regulation of receptor-mediated endocytosis
clathrin-coated vesicle
extrinsic component of cytoplasmic side of plasma membrane
phosphatidylinositol-4,5-bisphosphate binding
regulation of epidermal growth factor receptor signaling pathway
postsynapse
activation of cysteine-type endopeptidase activity involved in apoptotic process
phosphatidylinositol binding
regulation of ERBB signaling pathway
presynapse
regulation of receptor-mediated endocytosis
positive regulation of endocytosis
structural constituent of cytoskeleton
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of protein kinase B signaling
positive regulation of endopeptidase activity
protein stabilization