HIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= HIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIP1
  * **<color #00a2e8>Official Name</color>**: huntingtin interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3092|3092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00291|O00291]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I LWEQ|
|ENTH|
|ANTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of platelet-derived growth factor receptor-beta signaling pathway|
|extrinsic component of postsynaptic membrane|
|extrinsic component of presynaptic membrane|
|positive regulation of platelet-derived growth factor receptor signaling pathway|
|glutamate receptor binding|
|clathrin light chain binding|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|AP-2 adaptor complex binding|
|clathrin adaptor activity|
|AP-2 adaptor complex|
|actin cortical patch|
|clathrin coat assembly|
|regulation of platelet-derived growth factor receptor signaling pathway|
|clathrin-dependent endocytosis|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|positive regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor binding|
|positive regulation of ERBB signaling pathway|
|neurotransmitter receptor transport|
|clathrin binding|
|phosphatidylinositol-3-phosphate binding|
|positive regulation of receptor-mediated endocytosis|
|clathrin-coated vesicle|
|extrinsic component of cytoplasmic side of plasma membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of epidermal growth factor receptor signaling pathway|
|postsynapse|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|phosphatidylinositol binding|
|regulation of ERBB signaling pathway|
|presynapse|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|structural constituent of cytoskeleton|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of protein kinase B signaling|
|positive regulation of endopeptidase activity|
|protein stabilization|
|positive regulation of peptidase activity|
|actin filament binding|
|regulation of endocytosis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein kinase B signaling|
|receptor-mediated endocytosis|
|actin filament organization|
|regulation of cysteine-type endopeptidase activity|
|protein-containing complex localization|
|apoptotic signaling pathway|
|regulation of protein stability|
|glutamatergic synapse|
|positive regulation of proteolysis|
|cytoskeleton|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|supramolecular fiber organization|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|regulation of vesicle-mediated transport|
|endocytosis|
|actin filament-based process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|apoptotic process|
|Golgi apparatus|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.96|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.9|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.89|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.49|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9095
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIP1 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>