SLC25A27

Entrez Summary: N/A
UniProt Summary: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitochondrial calcium ion concentration
cellular triglyceride homeostasis
negative regulation of mitochondrial membrane potential
negative regulation of membrane potential
mitochondrial calcium ion homeostasis
acylglycerol homeostasis
triglyceride homeostasis
response to cold
neuron death
regulation of glucose import
regulation of mitochondrial membrane potential
apical part of cell
regulation of glucose transmembrane transport
mitochondrial membrane
lipid homeostasis
proton transmembrane transport
response to temperature stimulus
inner ear development
ear development
neuronal cell body
mitochondrial inner membrane
monovalent inorganic cation transport
regulation of membrane potential
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
sensory organ development
cellular metal ion homeostasis
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis