MED1
Gene Information
- Official Symbol: MED1
- Official Name: mediator complex subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5469
- UniProt: Q15648
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008].
- UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Pfam Domains GO Terms
Pfam Domains
| Med1 |
GO Terms
| enucleate erythrocyte development |
| thyroid hormone mediated signaling pathway |
| retinal pigment epithelium development |
| positive regulation of G0 to G1 transition |
| thyroid hormone receptor coactivator activity |
| epithelial cell proliferation involved in mammary gland duct elongation |
| mediator complex binding |
| branch elongation involved in mammary gland duct branching |
| mammary gland branching involved in thelarche |
| thelarche |
| mammary gland branching involved in pregnancy |
| positive regulation of response to interferon-gamma |
| regulation of vitamin D receptor signaling pathway |
| positive regulation of interferon-gamma-mediated signaling pathway |
| development of secondary female sexual characteristics |
| peroxisome proliferator activated receptor signaling pathway |
| enucleate erythrocyte differentiation |
| LBD domain binding |
| positive regulation of hepatocyte proliferation |
| development of secondary sexual characteristics |
| androgen biosynthetic process |
| peroxisome proliferator activated receptor binding |
| thyroid hormone generation |
| positive regulation of intracellular estrogen receptor signaling pathway |
| mammary gland epithelial cell proliferation |
| retinoic acid receptor binding |
| negative regulation of keratinocyte proliferation |
| regulation of hepatocyte proliferation |
| positive regulation of intracellular steroid hormone receptor signaling pathway |
| vitamin D receptor binding |
| cellular response to thyroid hormone stimulus |
| thyroid hormone metabolic process |
| positive regulation of keratinocyte differentiation |
| ventricular trabecula myocardium morphogenesis |
| cellular response to hepatocyte growth factor stimulus |
| mononuclear cell differentiation |
| monocyte differentiation |
| megakaryocyte development |
| branch elongation of an epithelium |
| response to hepatocyte growth factor |
| mRNA transcription by RNA polymerase II |
| nuclear receptor binding |
| embryonic hemopoiesis |
| megakaryocyte differentiation |
| branching involved in mammary gland duct morphogenesis |
| positive regulation of epidermal cell differentiation |
| regulation of response to interferon-gamma |
| regulation of response to nutrient levels |
| regulation of interferon-gamma-mediated signaling pathway |
| regulation of response to extracellular stimulus |
| bone cell development |
| mRNA transcription |
| nuclear hormone receptor binding |
| response to thyroid hormone |
| androgen metabolic process |
| axis elongation |
| embryonic hindlimb morphogenesis |
| ERK1 and ERK2 cascade |
| thyroid hormone receptor binding |
| positive regulation of erythrocyte differentiation |
| mammary gland duct morphogenesis |
| regulation of transcription by RNA polymerase I |
| heart trabecula morphogenesis |
| erythrocyte development |
| regulation of keratinocyte proliferation |
| RNA polymerase II core promoter sequence-specific DNA binding |
| positive regulation of signaling receptor activity |
| hindlimb morphogenesis |
| mediator complex |
| positive regulation of epidermis development |
| regulation of keratinocyte differentiation |
| regulation of intracellular estrogen receptor signaling pathway |
| mammary gland morphogenesis |
| estrogen receptor binding |
| cellular response to epidermal growth factor stimulus |
| regulation of G0 to G1 transition |
| protein-DNA complex |
| lactation |
| trabecula morphogenesis |
| regulation of erythrocyte differentiation |
| steroid hormone biosynthetic process |
| response to epidermal growth factor |
| ventricular cardiac muscle tissue morphogenesis |
| positive regulation of cytokine-mediated signaling pathway |
| ventricular cardiac muscle tissue development |
| positive regulation of response to cytokine stimulus |
| mammary gland epithelium development |
| myeloid cell development |
| positive regulation of epithelial cell differentiation |
| hormone biosynthetic process |
| regulation of epidermal cell differentiation |
| maternal process involved in female pregnancy |
| nuclear receptor transcription coactivator activity |
| cardiac muscle tissue morphogenesis |
| intracellular steroid hormone receptor signaling pathway |
| chromatin DNA binding |
| animal organ regeneration |
| cardiac ventricle morphogenesis |
| body fluid secretion |
| embryonic heart tube development |
| regulation of intracellular steroid hormone receptor signaling pathway |
| lens development in camera-type eye |
| muscle tissue morphogenesis |
| erythrocyte differentiation |
| positive regulation of animal organ morphogenesis |
| transcription coregulator activity |
| phenol-containing compound metabolic process |
| regulation of epidermis development |
| epithelial cell proliferation |
| muscle organ morphogenesis |
| embryonic placenta development |
| erythrocyte homeostasis |
| positive regulation of myeloid cell differentiation |
| protein import into nucleus |
| gland morphogenesis |
| ubiquitin ligase complex |
| fat cell differentiation |
| myeloid cell homeostasis |
| myeloid leukocyte differentiation |
| import into nucleus |
| developmental growth involved in morphogenesis |
| chromatin |
| steroid hormone mediated signaling pathway |
| cellular hormone metabolic process |
| negative regulation of epithelial cell proliferation |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| liver development |
| cardiac chamber morphogenesis |
| steroid biosynthetic process |
| cardiac ventricle development |
| mammary gland development |
| hepaticobiliary system development |
| branching morphogenesis of an epithelial tube |
| retina development in camera-type eye |
| regulation of epithelial cell differentiation |
| protein import |
| appendage morphogenesis |
| limb morphogenesis |
| placenta development |
| regeneration |
| morphogenesis of a branching epithelium |
| cardiac muscle tissue development |
| protein localization to nucleus |
| intracellular receptor signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| morphogenesis of a branching structure |
| cardiac chamber development |
| hormone-mediated signaling pathway |
| regulation of signaling receptor activity |
| transcription initiation from RNA polymerase II promoter |
| regulation of response to cytokine stimulus |
| female pregnancy |
| appendage development |
| limb development |
| positive regulation of hemopoiesis |
| cellular response to steroid hormone stimulus |
| positive regulation of epithelial cell proliferation |
| cellular modified amino acid metabolic process |
| homeostasis of number of cells |
| bone development |
| hormone metabolic process |
| multi-multicellular organism process |
| DNA-templated transcription, initiation |
| myeloid cell differentiation |
| ubiquitin protein ligase activity |
| negative regulation of neuron differentiation |
| regulation of myeloid cell differentiation |
| transcription corepressor activity |
| heart morphogenesis |
| regulation of animal organ morphogenesis |
| steroid metabolic process |
| nucleocytoplasmic transport |
| nuclear transport |
| keratinocyte differentiation |
| transcription coactivator activity |
| striated muscle tissue development |
| positive regulation of cell cycle process |
| negative regulation of neurogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| camera-type eye development |
| epidermal cell differentiation |
| angiogenesis |
| response to steroid hormone |
| leukocyte differentiation |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| positive regulation of innate immune response |
| eye development |
| visual system development |
| positive regulation of response to biotic stimulus |
| sensory system development |
| MAPK cascade |
| positive regulation of cell cycle |
| in utero embryonic development |
| skin development |
| developmental growth |
| growth |
| signal transduction by protein phosphorylation |
| chromatin binding |
| regulation of lipid metabolic process |
| blood vessel morphogenesis |
| gland development |
| epidermis development |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| establishment of protein localization to organelle |
| embryonic organ development |
| regulation of hemopoiesis |
| regulation of innate immune response |
| organic hydroxy compound metabolic process |
| positive regulation of defense response |
| muscle structure development |
| transcription by RNA polymerase II |
| blood vessel development |
| skeletal system development |
| regulation of body fluid levels |
| cellular response to growth factor stimulus |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of multi-organism process |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| heart development |
| response to growth factor |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| sensory organ development |
| cell population proliferation |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| lipid biosynthetic process |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| protein ubiquitination |
| mRNA metabolic process |
| negative regulation of cell differentiation |
| cell morphogenesis |
| protein localization to organelle |
| brain development |
| regulation of cell cycle process |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| head development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| multi-organism reproductive process |
| negative regulation of cell death |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 284/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 14/28 |
| blood | 22/28 |
| bone | 7/25 |
| breast | 14/33 |
| central nervous system | 17/56 |
| cervix | 1/4 |
| colorectal | 5/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 6/15 |
| kidney | 4/21 |
| liver | 5/20 |
| lung | 22/75 |
| lymphocyte | 7/14 |
| ovary | 10/26 |
| pancreas | 13/24 |
| peripheral nervous system | 7/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 12/24 |
| soft tissue | 3/7 |
| thyroid | 1/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 15/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 109
- Expression level (log2 read counts): 7.21
Expression Distribution
MED1 Expression in NALM6 Cells: 7.21
