JAGN1 [The Human Chemical-Genetic Interaction Map Project]

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======= JAGN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JAGN1
  * **<color #00a2e8>Official Name</color>**: jagunal homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84522|84522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5M9|Q8N5M9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JAGN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAGN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616012|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129144, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1352|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to tunicamycin|
|response to tunicamycin|
|granulocyte colony-stimulating factor signaling pathway|
|neutrophil differentiation|
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|granulocyte differentiation|
|defense response to fungus|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|response to fungus|
|endoplasmic reticulum organization|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of hormone secretion|
|neutrophil migration|
|granulocyte migration|
|myeloid leukocyte differentiation|
|cellular response to antibiotic|
|myeloid leukocyte migration|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|myeloid cell differentiation|
|negative regulation of secretion|
|regulation of hormone secretion|
|response to antibiotic|
|leukocyte differentiation|
|leukocyte migration|
|endomembrane system organization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|myeloid leukocyte mediated immunity|
|regulation of hormone levels|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|defense response to other organism|
|cell migration|
|secretion by cell|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|regulation of protein localization|
|export from cell|
|localization of cell|
|cell motility|
|immune effector process|
|response to cytokine|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.13|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.84|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.78|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16810
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JAGN1 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>